In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 130, No. suppl_2 ( 2014-11-25)
Abstract:
Backgrounds: Cardiac rehabilitation with exercise training (CR/ET) has been reported to be associated with reduction in C-Reactive Protein (CRP). In patients with acute coronary syndrome receiving statin therapy, achievement of CRP levels below 2mg/L is known to be important for long-term event-free survival. However, the determinants of achieving low CRP after CR/ET are not fully understood. Methods: To address this issue, we studied 490 consecutive acute myocardial infarction (AMI) patients who participated in our CR/ET program and underwent measurements for serum CRP at the beginning and the end of the 3-month CR program. Patients with abnormally high CRP ( 〉 = 20mg/L at baseline, 〉 =10mg/L at 3 months) or on hemodialysis were excluded. Patients were divided into 2 groups according to CRP levels at the end of the 3-month CR/ET: Low-CRP group (CRP 〈 =2.0mg/L, n=414), and High-CRP group (CRP 〉 2.0mg/dl, n=76). Results: At baseline, there were no significant differences between the two groups in age (Low-CRP group 64years vs High-CRP group 63years, NS), body mass index (BMI, 23 vs 23, NS), prevalences of diabetes, smoking habit and statin use, left ventricular ejection fraction (LVEF, 46 vs 44%, NS), or brain natriuretic peptide (BNP) levels (169 vs 164pg/ml, NS). Although the prevalence of dyslipidemia was significantly higher (76% vs 63%, p 〈 0.05), baseline CRP levels (4.5mg/L vs 5.9mg/L, p 〈 0.05) was significantly lower in Low-CRP group than High-CRP group. Notably, Low-CRP group had significantly greater number of attendance in CR/ET in 3 months than High-CRP group (18 vs 14times, p 〈 0.01). Multivariate logistic regression analysis (incorporating age, sex, BMI, history of dyslipidemia, baseline LVEF, peak CK, number of attendance in 3-month CR/ET, BNP, CRP, and statin use) demonstrated that history of dyslipidemia, lower baseline CRP levels, and greater number of 3-month CR/ET attendance were independent determinants (all p 〈 0.05) of achieving CRP levels below 2.0mg/L. Conclusion: Good attendance in CR/ET program is significantly associated with achievement of CRP levels below 2.0mg/L at 3 months, independent of baseline CRP levels, history of dyslipidemia, and statin use.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.130.suppl_2.17518
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2014
detail.hit.zdb_id:
1466401-X
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