In:
Oncology, S. Karger AG, Vol. 93, No. Suppl. 1 ( 2017), p. 55-60
Abstract:
〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 This study evaluated whether quantitative perfusion analysis with contrast-enhanced harmonic (CH) endoscopic ultrasonography (EUS) characterizes pancreatic tumors, and compared the hemodynamic parameters used to diagnose pancreatic carcinoma. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 CH-EUS data from pancreatic tumors of 76 patients were retrospectively analyzed. Time-intensity curves (TIC) were generated to depict changes in signal intensity over time, and 6 parameters were assessed: baseline intensity, peak intensity, time to peak, intensity gain, intensity at 60 s (I 〈 sub 〉 60 〈 /sub 〉 ), and reduction rate. These parameters were compared between pancreatic carcinomas ( 〈 i 〉 n 〈 /i 〉 = 41), inflammatory pseudotumors ( 〈 i 〉 n 〈 /i 〉 = 14), pancreatic neuroendocrine tumors ( 〈 i 〉 n 〈 /i 〉 = 14), and other tumors ( 〈 i 〉 n 〈 /i 〉 = 7). All 6 TIC parameters and subjective analysis for diagnosing pancreatic carcinoma were compared. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Values of peak intensity and I 〈 sub 〉 60 〈 /sub 〉 were significantly lower and time to peak was significantly longer in the groups with pancreatic carcinomas than in the other 3 tumor groups ( 〈 i 〉 p 〈 /i 〉 〈 0.05). Reduction rate was significantly higher in pancreatic carcinomas than in pancreatic neuroendocrine tumors ( 〈 i 〉 p 〈 /i 〉 〈 0.05). Areas under the receiver-operating characteristic curves for the diagnosis of pancreatic carcinoma using subjective analysis, baseline intensity, peak intensity, intensity gain, I 〈 sub 〉 60 〈 /sub 〉 , time to peak, and reduction rate, were 0.817, 0.664, 0.810, 0.751, 0.845, 0.777, and 0.725, respectively. I 〈 sub 〉 60 〈 /sub 〉 was the most accurate parameter for differentiating pancreatic carcinomas from the other groups, giving values of sensitivity/specificity of 92.7/68.6% when optimal cutoffs were chosen. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In pancreatic carcinomas, TIC patterns were markedly different from the other tumor types, with I 〈 sub 〉 60 〈 /sub 〉 being the most accurate diagnostic parameter. Quantitative perfusion analysis is useful for differentiating pancreatic carcinomas from other pancreatic tumors.
Type of Medium:
Online Resource
ISSN:
0030-2414
,
1423-0232
Language:
English
Publisher:
S. Karger AG
Publication Date:
2017
detail.hit.zdb_id:
1483096-6
detail.hit.zdb_id:
250101-6
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