In:
IOP Conference Series: Materials Science and Engineering, IOP Publishing, Vol. 544, No. 1 ( 2019-07-01), p. 012029-
Abstract:
In Vietnam, the medicinal plant Scoparia dulcis is used for the treatment of bronchitis, gastric disorders, antidiabetes, hypertension, hepatitis etc. In this paper, experiments was designed to evaluate in vitro anticancer and anti-inflammatory activities and isolate phytochemicals from methanol extracts of Scoparia dulcis whole plants. The chemical investigation of methanol fraction of Scoparia dulcis led to the isolation of benzoxazinone (1), phenylethanoid (2), flavone (3), and lignan (4) glycosides. The bioactivity results indicated that crude ethanol and ethyl acetate extracts had potent cytotoxic activity toward the HepG2 cancer cell with IC50 of 47.03 μg/mL and 36.04 μg/mL, respectively. Interestingly, crude ethanol and ethyl acetate extracts had the NO inhibitory activity, with inhibition of 56.9 % or 74.7 % at 30 μg/mL and 97.3% or 82.9 % at 100 μg/mL, respectively. In addition, the hexane extract at concentrations of 100 μg/ml demonstrated anti-inflammatory activity through the inhibition of nitric oxide production of 76.7%.
Type of Medium:
Online Resource
ISSN:
1757-8981
,
1757-899X
DOI:
10.1088/1757-899X/544/1/012029
Language:
Unknown
Publisher:
IOP Publishing
Publication Date:
2019
detail.hit.zdb_id:
2506501-4
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