In:
Chemistry & Biodiversity, Wiley, Vol. 14, No. 8 ( 2017-08)
Abstract:
Phaeanthus vietnamensis B ân is a well‐known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7 S ,8 R ,8′ R )‐9,9′‐epoxy‐3,5,3′,5′‐tetramethoxylignan‐4,4′,7‐triol ( 1 ), 8 α ‐hydroxyoplop‐11(12)‐en‐14‐one ( 5 ), and (1 R ,2 S ,4 S )‐4‐acetyl‐2‐[( E )‐(cinnamoyloxy)]‐1‐methylcyclohexan‐1‐ol ( 12 ) along with twelve known compounds were isolated from the leaves of P . vietnamensis . Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS ‐stimulated BV 2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS ‐stimulated NO production in BV 2 cells with the IC 50 values of 15.7 ± 1.2 μ m . Compounds 2 , 7 , and 8 significantly inhibited inflammatory NO production with IC 50 values ranging from 22.6 to 25.3 μ m .
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.201700013
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2139001-0
SSG:
12
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