In:
Transfusion, Wiley, Vol. 54, No. 6 ( 2014-06), p. 1523-1529
Abstract:
Allergic transfusion reaction ( ATR ) incidence ranges from 1% to 3% of all transfusions. We evaluated the impact of InterSol platelet additive solution ( PAS ) apheresis platelets ( AP s) on the incidence of ATR s and the posttransfusion platelet ( PLT ) increment. Study Design and Methods This retrospective study evaluated all ATR s among patients at a university hospital that maintained a mixed inventory of PAS AP s and non‐ PAS AP s (standard plasma‐suspended PLTs ). Corrected count increments ( CCIs ) were calculated for AP transfusions of individuals who received both a PAS and a non‐ PAS AP transfusion within a 7‐day period. Hypothesis testing was performed with chi‐square test for dichotomous variables and t tests for continuous variables. Results The incidence of ATR s among the non‐ PAS AP s was 1.85% (72 ATR s/3884 transfusions) and 1.01% (12 ATR s/1194 transfusions) for PAS AP s (risk ratio [ RR ], 0.54; 95% confidence interval [ CI ] = 0.30‐0.99; p = 0.04). However, there was no difference in the incidence of febrile nonhemolytic transfusion reactions between non‐ PAS AP s (incidence, 0.70%; 27/3884) compared to PAS AP s (incidence, 0.59%; 7/1194; p = 0.69). Among 223 individuals with paired non‐ PAS and PAS AP transfusions, the mean CCI at 1 to 4 hours after transfusion was 4932 (95% CI , 4452‐5412) for non‐ PAS AP s and was lower for PAS AP s ( CCI , 3766; 95% CI , 3375‐4158; p ≤ 0.001). However, there was no significant difference in mean CCI at 12 to 24 hours between non‐ PAS ( CCI , 2135; 95% CI , 1696‐2573) and PAS AP s ( CCI , 1745; 95% CI , 1272‐2217; p = 0.14). Conclusions PAS AP s substantially reduce the number of ATR s. CCI s for PAS AP s were lower immediately after transfusion, but not significantly different at 12 to 24 hours.
Type of Medium:
Online Resource
ISSN:
0041-1132
,
1537-2995
DOI:
10.1111/trf.2014.54.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2018415-3
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