In:
Oncology Research and Treatment, S. Karger AG, Vol. 45, No. 4 ( 2022), p. 197-204
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Radiation dermatitis (RD) is a side effect of radiation therapy (RT) which is experienced by over 90% of patients being treated for breast cancer. The current clinical trial was conducted to measure the preventative effects of a boron-based gel on several different clinical outcomes (dermatitis, erythema, dry desquamation, and moist desquamation) after 25 radiotherapy sessions. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This research used a double-blind parallel-group design with a placebo control ( 〈 i 〉 n 〈 /i 〉 = 76) and randomized group ( 〈 i 〉 n 〈 /i 〉 = 181), with all participants being between 18 and 75 years old. Fifteen minutes before each radiotherapy, participants in the intervention group were given a gel containing 3% sodium pentaborate pentahydrate, while those in the placebo group received a gel with no chemical substance. Dermatitis, erythema, dry desquamation, and moist desquamation were compared between the 2 groups. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At baseline, there were no significant differences between the groups ( 〈 i 〉 p 〈 /i 〉 & #x3e; 0.05), except for body mass index. After 14 days of treatment, dermatitis (98.7% vs. 9.9%; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), erythema (96.1% vs. 12.2%; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), dry desquamation (50% vs. 3.9%; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), and moist desquamation (18.4% vs. 0.6%; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001) were much more common in the placebo group than the intervention group. To prevent dermatitis, erythema, dry desquamation, and moist desquamation in 1 patient, on average, 1.1 (95% confidence interval [CI]: 1.1–1.2), 1.2 (95% CI: 1.1–1.3), 2.2 (95% CI: 1.7–2.9), and 5.6 (95% CI: 3.8–11.0) patients need to be treated, respectively. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The boron-based gel has a significant preventive effect on several categories of RD which might be used by clinicians in breast cancer.
Type of Medium:
Online Resource
ISSN:
2296-5270
,
2296-5262
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
2749752-5
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