In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 124, No. suppl_21 ( 2011-11-22)
Abstract:
Background: The long-term detailed changes of neointima coverage and characteristics in Sirolimus-eluting stent(SES) and Paclitaxel-eluting stent(PES) remains to be clarified. Methods: Of 18 SES (14 patients) and 13 PES (12 patients), OCT was used to visualize 2486 and 1361 stent-struts at 8 months after implantation 2199 and 1309 stent-struts at 20 months after respectively. The OCT parameters, including incidence of uncovered struts and malapposed struts and neiointimal hyperplasia thickness (NIH thickness) and NIH% were compared between SES and PES and between 8 months after and 20 months after for SES and PES.,The neointimal charecteristics were classified into 3 groups:high without PLIA(high density neointima without peri-strut low-intensity area(PLIA),high with PLIA and non-high .PLIA was defined as a region around stent struts with a homogeneous,lower intensity appearance Results: Uncovered ratio and malapposed ratio was significantly higher in SES than in PES both at both follow-up. NIH thickness and %NIH was higher in PES than in SES at both follow-up. Uncovered ratio significantly decreased in SES from 8months to 20months after, and in PES nonsiginificantly decreased . Malapposed ratio nonsignificantly decreased in both groups. NIH% and NIH thickness significantly increased in SES ,but NIH% and NIH thickness significantly decreased in PES from 8months after to 20months after. High signal neointima accounts for more than 90% in both groups.However it decreased in SES ,while increased in PES. High with PLIA nonsignificantly increased in SES ,but decreased in PES. Non-high signal neointima decreased both in SES and in PES.(Table) Conclusions: Uncovered struts and malapposed struts gradually alleviated in both SES and PES while neointimal hyperplasia condition and characteristics showed different patters; increasing in SES but decreasing in PES.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.124.suppl_21.A8634
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2011
detail.hit.zdb_id:
1466401-X
detail.hit.zdb_id:
80099-5
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