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  • Oxford University Press (OUP)  (11)
  • Naito, Makoto  (11)
  • 1
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    Immunophenotypic and ultrastructural heterogeneity of macrophage differentiation in bone marrow and fetal hematopoiesis of mouse in vitro and in vivo
    Oxford University Press (OUP) ; 1994
    In:  Journal of Leukocyte Biology Vol. 55, No. 5 ( 1994-05-01), p. 642-651
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 55, No. 5 ( 1994-05-01), p. 642-651
    Abstract: The present in vitro study revealed marked differences in immunophenotypic expression and ultrastructure among macrophage colony-stimulating factor (M-CSF)–derived, granulocyte-macrophage colony-stimulating factor (GM-CSF)–derived, and multi-CSF–derived macrophages. M-CSF–derived macrophages were larger and had more markedly differentiated intracellular organelles and more cytoplasmic projections than GM-CSF–or multi-CSF–derived macrophages. By the combined method of ultrastructural peroxidase cytochemistry and immunoelectron microscopy, ER-MP12 was demonstrated mainly on blastic cells; ER-MP20 on promonocytes, monocytes, and immature macrophages; and F4/80 or BM8 on immature and mature macrophages and monocytes. Macrophage heterogeneity was demonstrated to occur at the stage of macrophage precursor cells, and macrophage differentiation was different between bone marrow hematopoiesis and early fetal hematopoiesis. In vivo, F4/80- or BM8-positive (+) macrophages and ER-MP12 (+) cells developed in the yolk sac prior to the appearance of ER-MP20 (+) monocytic cell series. These results imply that CSFs are important factors for the generation of phenotypic heterogeneity of macrophage populations not only in bone marrow but also in fetal hematopoiesis, suggesting that there are different pathways of macrophage differentiation. J. Leukoc. Biol. 55: 642–651; 1994.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.55.5.642
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1994
    detail.hit.zdb_id: 2026833-6
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  • 2
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    Development, differentiation, and proliferation of epidermal Langerhans cells in rat ontogeny studied by a novel monoclonal antibody against epidermal Langerhans cells, RED-1
    Oxford University Press (OUP) ; 1992
    In:  Journal of Leukocyte Biology Vol. 52, No. 1 ( 1992-07-01), p. 52-61
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 52, No. 1 ( 1992-07-01), p. 52-61
    Abstract: An antirat monoclonal antibody (mAb) against nonlymphoid dendritic cells, RED-1, was produced using epidermal Langerhans cells (LCs) as the immunogen. This mAb reacted mainly with the LCs and indeterminate dendritic cells (ICs), interdigitating cells in the T cell areas of lymphoid tissues, and monocyte/macrophages in various organs and tissues of adult rats. In the epidermal sheets prepared from adult rats, it specifically recognized the cell surface antigen(s) present on LCs and ICs. In the fetal rat skin, primitive or fetal macrophages migrated into the epidermis and expressed RED-1 at fetal day 17. With advance of gestation, RED-1–positive cells increased, started expressing Ia antigens at fetal day 18, and subsequently differentiated into dendritic cells. Most of them showed Ia expression by fetal day 20 and differentiated into LCs within a few days after birth. The labeling index of 5-bromo-2′-deoxyuridine in RED-1–positive cells was 18% at fetal day 17 and decreased to 5 to 6% in the postnatal period. These results imply that proliferative capacity of RED-1–positive cells is important for the formation and expansion of the IC population in the fetal stage and for the survival of LCs in the postnatal period.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.52.1.52
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1992
    detail.hit.zdb_id: 2026833-6
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  • 3
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    Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages
    Oxford University Press (OUP) ; 1996
    In:  Journal of Leukocyte Biology Vol. 59, No. 2 ( 1996-02-01), p. 133-138
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 59, No. 2 ( 1996-02-01), p. 133-138
    Abstract: In murine ontogeny, macrophage precursor cells develop in the yolk sac and fetal liver. Primitive macrophages also appear in the yolk sac, migrate to various tissues, and differentiate into several fetal macrophage populations. Because the development of the monocytic cell lineage is incomplete in the early stage of fetal hematopoiesis, primitive/fetal macrophages are considered to originate from granulocyte-macrophage colony-forming cells or earlier macrophage precursors, bypassing the early monocytic cell series. In adult mice rendered severely monocytopenic by administration of strontium-89, resident macrophages are maintained by self-renewal. In contrast, administration of liposome-encapsulated dichloromethylene diphosphonate (clodronate) results in the elimination of various tissue macrophage populations. The repopulation of affected macrophages is dependent on the increase of precursors in the liver and spleen during the period of macrophage depletion. Such precursors reconstitute heterogeneous macrophage subpopulations. In mice homozygous for the osteopetrosis (op) mutation, the absence of macrophage colony-stimulating factor (M-CSF) activity results in a deficiency of monocytes and monocyte-derived macrophages. However, immature macrophages are present in various tissues. Administration of M-CSF to op/op mice induces the increased proliferative capacity and the morphological maturation of macrophages. However, the responses of individual tissue macrophage subpopulations to M-CSF are different. These results indicate that macrophage development, differentiation, and proliferation are regulated by the tissue microenvironment including the in situ production of macrophage growth factors in both fetal and adult life.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.59.2.133
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1996
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  • 4
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    Development, Differentiation, and Maturation of Fetal Mouse Yolk Sac Macrophages in Cultures
    Oxford University Press (OUP) ; 1989
    In:  Journal of Leukocyte Biology Vol. 46, No. 1 ( 1989-07-01), p. 1-10
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 46, No. 1 ( 1989-07-01), p. 1-10
    Abstract: The development and differentiation of macrophages in the fetal mouse yolk sac were studied morphologically in four different culture experiments. In the culture of mouse embryos with yolk sac, the development of fetal macrophages was demonstrated to precede that of promonocytes and monocytes in the yolk sac. In vitro differentiation of the fetal macrophages was consistent with the results of our previous in vivo observation indicating that fetal macrophages were differentiated from primitive macrophages, but not from the monocytic cell series. Differentiation of primitive macrophages into fetal macrophages, before the development of promonocytes and monocytes, was reproduced in the culture of cell suspensions from the fetal mouse yolk sacs, with a mouse bone marrow stromal cell clone (ST2) particularly with those at 8 days of gestation. In the soft agar or liquid culture of yolk sac cells with LP3-conditioned medium, monocyte-macrophage colonies were effectively induced, but not fetal macrophage colonies. The results provide evidence for the existence, in yolk sac hematopoiesis, of two distinct macrophage populations: a fetal macrophage population and a monocyte-derived macrophage population. The data indicate an obvious difference in development and differentiation between the two populations and the temporal precedence of fetal macrophages appearing before monocyte-macrophages.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.46.1.1
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1989
    detail.hit.zdb_id: 2026833-6
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  • 5
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    Development, Differentiation, and Maturation of Macrophages in the Fetal Mouse Liver
    Oxford University Press (OUP) ; 1990
    In:  Journal of Leukocyte Biology Vol. 48, No. 1 ( 1990-07-01), p. 27-37
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 48, No. 1 ( 1990-07-01), p. 27-37
    Abstract: Primitive macrophages emerged in the sinusoidal lumen of the fetal mouse liver at 10 days of gestation before the Initiation of hepatic hematopoiesis and matured into fetal macrophages. In the culture of cell suspensions from the fetal liver with LP3-conditioned medium, monocyte colonies were formed, but monocytopoiesis was poor in the early stage of hepatic hematopoiesis in vivo. In the culture of cell suspensions obtained from the fetal liver at 10 days of gestation on the monolayer of a mouse bone marrow stromal cell line, ST2, primitive/fetal macrophage colonies were formed before the development of monocyte/macrophage colonies and showed differentiation of primitive macrophages into fetal macrophages without passing through the stage of promonocytes and monocytes. At this time, the fetal cardiovascular system was connected with the vitelline vein just before the formation of the liver. With the progress of gestation, a monocytic cell series was observed to develop and form a monocyte/macrophage population. This was confirmed by in vitro studies with an LP3-conditioned medium and on a monolayer of ST2. Thus, it appears that there exist two different macrophage populations, a primitive/ fetal macrophage population and a monocyte/macrophage population in hepatic hematopoiesis. It also appears that fetal macrophages are differentiated from primitive macrophages which are colonized into the fetal liver from the yolk sac or which develop in loco, presumably from hematopoietic stem cells.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.48.1.27
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1990
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  • 6
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    Kupffer Cell Proliferation and Glucan-Induced Granuloma Formation in Mice Depleted of Blood Monocytes by Strontium-89
    Oxford University Press (OUP) ; 1990
    In:  Journal of Leukocyte Biology Vol. 47, No. 3 ( 1990-03-01), p. 195-205
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 47, No. 3 ( 1990-03-01), p. 195-205
    Abstract: In mice with prolonged severe monocytopenia induced by selective irradiation of the bone marrow with the bone-seeking isotope 89Sr, the proliferative capacity of Kupffer cells was studied by immunohistochemistry with an anti-mouse macrophage monoclonal antibody, F4/80, ultrastructural peroxidase (PO) cytochemistry, and tritiated thymidine (3HTdR) autoradiography. The number and 3HTdR uptake of Kupffer cells were significantly increased in the splenectomized mice after severe monocytopenia had continued for more than 4 wk, and almost all the Kupffer cells showed a localization pattern of PO activity similar to that of resident macrophages in the liver of normal mice. In the glucan-induced granuloma formation in similar mortocytopenic mice, Kupffer cells proliferated. conglomerated, and transformed into epithelioid cells, which fused together to become multinuclear giant cells. These results suggest that Kupffer cells are a self-renewing population by their own cell division and can participate actively in granulomatous inflammations in severely monocytopenic and intact mice.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.47.3.195
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1990
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  • 7
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    Development, Differentiation, and Maturation of Macrophages in the Chorionic Villi of Mouse Placenta With Special Reference to the Origin of Hofbauer Cells
    Oxford University Press (OUP) ; 1991
    In:  Journal of Leukocyte Biology Vol. 50, No. 1 ( 1991-07-01), p. 57-68
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 50, No. 1 ( 1991-07-01), p. 57-68
    Abstract: In blood vessels of the chorionic villi of mouse placenta, primitive macrophages first emerged at 10 days of gestation, then differentiated and matured into fetal macrophages. After emigration into the chorionic villous mesenchymal stroma, they ingested fluid-like stromal materials and transformed into Hofbauer cells. In our observation of their differentiation and maturation, no promonocytes or monocytes were detected. In the culture of cell suspensions from the placenta with LP3-conditioned medium, CFU-GM was confirmed, but in the culture with the mouse bone marrow stromal cell line (ST2) the primitive/fetal macrophage population occurred predominantly before the development of the monocyte/macrophage population. Proliferative potential of the primitive and fetal macrophages is slight. With the progress of gestation, the monocyte/macrophage population appeared in the chorionic villous stroma, forming a heterogeneous population of placental macrophages in the late fetal stage.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.50.1.57
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1991
    detail.hit.zdb_id: 2026833-6
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  • 8
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    Differentiation, Maturation, and Proliferation of Macrophages in the Mouse Yolk Sac: A Light-Microscopic, Enzyme-Cytochemical, Immunohistochemical, and Ultrastructural Study
    Oxford University Press (OUP) ; 1989
    In:  Journal of Leukocyte Biology Vol. 45, No. 2 ( 1989-02-01), p. 87-96
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 45, No. 2 ( 1989-02-01), p. 87-96
    Abstract: Primitive macrophages first appear in the blood islands of the mouse yolk sac on the ninth day of gestation. After the tenth day of fetal life, these cells differentiate into fetal macrophages and become mature, with the development of intracellular organelles. They appear in the mesenchymal layer and further immigrate into the extraembryonic coelom. The fetal macrophages do not show any cytochemical peroxidase or 5′-nucleotidase activity, and they possess a marked proliferative capacity. Promonocytes or monocytes that have an incomplete ultrastructure emerge in the blood islands of the yolk sac a day after the occurrence of the fetal macrophages. These events suggest that fetal macrophages differentiate from primitive macrophages before the development of promonocytes or monocytes in the mouse yolk sac; they actively proliferate and are colonized into the embryonic tissues. These results also indicate that the ontogeny of the monocyte/macrophage is different in the early embryo compared with its later developmental stages.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.45.2.87
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1989
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  • 9
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    Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis ( op ) mutation
    Oxford University Press (OUP) ; 1993
    In:  Journal of Leukocyte Biology Vol. 53, No. 1 ( 1993-01-01), p. 19-28
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 53, No. 1 ( 1993-01-01), p. 19-28
    Abstract: In op/op mice, immunohistochemical and electron microscopic techniques were used to examine the effects of the OP mutation on dendritic cell populations in lymphoid tissues and skin. In the thymic medulla, T cell zone of lymph nodes, and splenic white pulp of op/op mice, numbers of NLDC-145-positive dendritic cells were not decreased. Compared to the normal litter- mates, numbers of BM8-positive macrophages were reduced in various tissues of the mutant mice, including the lymphoid tissues. These dendritic cells of op/op mice expressed la antigens but not F4/80 and BM8 antigens. Ultrastructurally, the dendritic cells developed a tubulo- vesicular system typical of interdigitating cells, but they were abnormal in that interdigitation of their cytoplasmic processes was not prominent. In the epidermis of the op/op mice, dendritic cells expressed NLDC-145, F4/80, la antigens, and adenosine diphosphatase or adenosine triphosphatase activity, and numbers of NLDC-145-, la-, or ADPase-positive dendritic cells were reduced slightly, but these reductions were not significant statistically. Bir- beck granules were detected in most of them electron microscopically. These results indicate that nonlymphoid dendritic cells develop in the lymphoid tissues and skin of op/op mouse, suggesting that they are differentiated from granulocyte-macrophage colony-forming cells or earlier hematopoietic cell precursors. J. Leukoc. Biol. 53: 19–28; 1993.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.53.1.19
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1993
    detail.hit.zdb_id: 2026833-6
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  • 10
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    Ontogenetic development, differentiation, and phenotypic expression of macrophages in fetal rat lungs
    Oxford University Press (OUP) ; 1992
    In:  Journal of Leukocyte Biology Vol. 51, No. 5 ( 1992-05-01), p. 444-454
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 51, No. 5 ( 1992-05-01), p. 444-454
    Abstract: Development, differentiation, and distribution of macrophages in fetal rat lungs were investigated immunohistochemically using anti-rat macrophage monoclonal antibodies. In the lung buds, RM-1+ macrophages were first detected on fetal day 13, and some showed reactivity for TRPM-2. They populated in the peribronchial mesenchyme of the lung buds, proliferated in loco, and showed no peroxidase activity in any intracellular organelles. Their immunophenotypic and ultrastructural features were consistent with those of primitive/fetal macrophages. By fetal day 16, some of them expressed ED1, but ED1+ cells were a minor subpopulation throughout the fetal period. On fetal day 18, ED2+ macrophages developed; some also were positive for RM-1, but the others were negative. Both the RM-1+ and ED2+ macrophages were major macrophage subpopulations and expressed Ki-M2R and/or TRPM-3; ED2+ and/or Ki-M2R+ cells are regarded as pulmonary interstitial resident macrophages. In organ culture, a similar expression of differentiation antigens by macrophages was confirmed. None of these macrophages cytochemically showed any peroxidase activity in vivo or in vitro. In the fetal stage, both RM-1+ and ED2+ macrophage subpopulations showed proliferative potential, suggesting their ability to proliferate and survive in vivo.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.51.5.444
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1992
    detail.hit.zdb_id: 2026833-6
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