In:
American Journal of Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 117, No. 7 ( 2022-07), p. 1158-1161
Abstract:
We assessed pharmacodynamics and pharmacokinetics of a potassium-competitive acid blocker and proton pump inhibitor in US subjects. METHODS: Healthy adults were randomized to 7-day periods of vonoprazan 20 mg once daily followed by lansoprazole 30 mg once daily or the reverse order, separated by ≥ 7 days of washout. RESULTS: Vonoprazan (N = 40) had higher proportions of 24-hour periods with intragastric pH 〉 4 than lansoprazole (N = 41,38) on day 1 (62.4% vs 22.6%, P 〈 0.0001) and day 7 (87.8% vs 42.3%, P 〈 0.0001). Separation in pH started ∼2.5 hours after the first dose. DISCUSSION: Vonoprazan provided more rapid and potent inhibition of intragastric acidity than lansoprazole in US subjects.
Type of Medium:
Online Resource
ISSN:
0002-9270
,
1572-0241
DOI:
10.14309/ajg.0000000000001735
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
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