In:
Annals of Nutrition and Metabolism, S. Karger AG, Vol. 48, No. 5 ( 2004), p. 329-334
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 Lipoprotein(a) synthesis and catabolism could be influenced by insulin or by diabetes metabolic complications in patients with type-1 diabetes. The aim of the study was to investigate the relation of plasma lipoprotein(a) concentrations with metabolic cardiovascular risk factors in Kuwaiti children with uncomplicated type-1 diabetes. 〈 i 〉 Methods: 〈 /i 〉 This case-control study included 115 (44 males and 71 females) diabetic children aged 6–18 years matched by age and sex to 115 non-diabetic children as controls. 〈 i 〉 Results: 〈 /i 〉 There was no significant difference between the mean lipoprotein(a) concentrations in type-1 diabetic children (27.34 mg/dl) and their controls (22.80 mg/dl). Total cholesterol, apolipoprotein A1 and B levels were significantly higher in diabetic children than controls. In diabetic children, significant correlations were found between lipoprotein(a) levels and glycated hemoglobin (r = 0.249, p = 0.011), total cholesterol (r = 0.208, p = 0.025), and apolipoprotein B (r = 0.349, p 〈 0.001). The proportion of diabetic children with lipoprotein(a) 〉 30 mg/dl was significantly higher in those having poor glycemic control (glycated hemoglobin 〉 9.0%, p = 0.013), raised total cholesterol (p = 0.033), or with a family history of cardiovascular disease (p = 0.006). 〈 i 〉 Conclusion: 〈 /i 〉 Plasma lipoprotein(a) levels were not elevated in young type-1 diabetic children compared to non-diabetic controls; however, lipoprotein(a) levels were significantly higher in diabetic children with poor glycemic control. Moreover, there were significant correlations between lipoprotein(a) and the metabolic cardiovascular risk factors total cholesterol, atherogenic index, apolipoprotein B and apolipoprotein B/A1 ratio.
Type of Medium:
Online Resource
ISSN:
0250-6807
,
1421-9697
Language:
English
Publisher:
S. Karger AG
Publication Date:
2004
detail.hit.zdb_id:
1481977-6
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