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  • 1
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    Which is better to use “body weight” or “standard liver weight”, for predicting small‐for‐size graft syndrome after living donor liver transplantation?
    Wiley ; 2021
    In:  Annals of Gastroenterological Surgery Vol. 5, No. 3 ( 2021-05), p. 363-372
    Details
    In: Annals of Gastroenterological Surgery, Wiley, Vol. 5, No. 3 ( 2021-05), p. 363-372
    Abstract: Little evidence about whether to apply graft‐to‐recipient body weight ratio (GRWR) or graft weight to standard liver weight (GW/SLW) for graft selection has been published. The aim of the present study was to clarify the importance of the correct use of GRWR and GW/SLW for selecting graft according to the recipients’ physique in living donor liver transplantation (LDLT). Methods Data were collected for 694 recipients who underwent LDLT between 1997 and 2020. Results One of the marginal grafts meeting GW/SLW ≥ 35% but GRWR  〈  0.7% has been used in more recipients with men and higher body mass index (BMI), and the other meeting GRWR ≥ 0.7% but GW/SLW  〈  35% has been used in more recipients with women with lower BMI. In the cohort of BMI  〉  30 kg/m 2 , the recipients with GRWR  〈  0.7% had a significantly higher incidence of small‐for‐size graft syndrome (SFSS) compared to those with GRWR ≥ 0.7% ( P  = 0.008, 46.2% vs 5.9%), and using the cutoff of GW/SLW  〈  35% could not differentiate. In contrast, in the cohort of BMI ≤ 30 kg/m 2 , the recipients with GW/SLW  〈  35% also had a significantly higher incidence of SFSS ( P  = 0.013, 16.9% vs 9.4%). Multivariate analysis showed that GRWR  〈  0.7% [odds ratio (OR) 14.145, P  = 0.048] was the independent risk factor for SFSS in obese recipients, and GW/SLW  〈  35% [OR 2.685, P  = 0.002] was the independent risk factor in non‐obese recipients. Conclusion Proper use of the formulas for calculating GRWR and GW/SLW in choosing graft according to recipient BMI is important, not only to meet metabolic demand for avoiding SFSS but also to ameliorate donor shortages.
    Type of Medium: Online Resource
    ISSN: 2475-0328 , 2475-0328
    URL: Issue
    URL: Article
    DOI: 10.1002/ags3.v5.3
    DOI: 10.1002/ags3.12412
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2895706-4
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  • 2
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    Systematic approaches to using the FOX hunting system to identify useful rice genes
    Wiley ; 2009
    In:  The Plant Journal Vol. 57, No. 5 ( 2009-03), p. 883-894
    Details
    In: The Plant Journal, Wiley, Vol. 57, No. 5 ( 2009-03), p. 883-894
    Abstract: Ectopic gene expression, or the gain‐of‐function approach, has the advantage that once the function of a gene is known the gene can be transferred to many different plants by transformation. We previously reported a method, called FOX hunting, that involves ectopic expression of Arabidopsis full‐length cDNAs in Arabidopsis to systematically generate gain‐of‐function mutants. This technology is most beneficial for generating a heterologous gene resource for analysis of useful plant gene functions. As an initial model we generated more than 23 000 independent Arabidopsis transgenic lines that expressed rice fl‐cDNAs (Rice FOX Arabidopsis lines). The short generation time and rapid and efficient transformation frequency of Arabidopsis enabled the functions of the rice genes to be analyzed rapidly. We screened rice FOX Arabidopsis lines for alterations in morphology, photosynthesis, element accumulation, pigment accumulation, hormone profiles, secondary metabolites, pathogen resistance, salt tolerance, UV signaling, high light tolerance, and heat stress tolerance. Some of the mutant phenotypes displayed by rice FOX Arabidopsis lines resulted from the expression of rice genes that had no homologs in Arabidopsis . This result demonstrated that rice fl‐cDNAs could be used to introduce new gene functions in Arabidopsis. Furthermore, these findings showed that rice gene function could be analyzed by employing Arabidopsis as a heterologous host. This technology provides a framework for the analysis of plant gene function in a heterologous host and of plant improvement by using heterologous gene resources.
    Type of Medium: Online Resource
    ISSN: 0960-7412 , 1365-313X
    URL: Issue
    URL: Article
    DOI: 10.1111/tpj.2009.57.issue-5
    DOI: 10.1111/j.1365-313X.2008.03733.x
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2020961-7
    SSG: 12
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  • 3
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    Relationship between consolidation tumor ratio and tumor‐infiltrating lymphocytes in small‐sized lung adenocarcinoma
    Wiley ; 2022
    In:  Thoracic Cancer Vol. 13, No. 15 ( 2022-08), p. 2134-2141
    Details
    In: Thoracic Cancer, Wiley, Vol. 13, No. 15 ( 2022-08), p. 2134-2141
    Abstract: Consolidation tumor ratio (CTR) is associated with cancer progression and histological invasiveness in lung adenocarcinoma (LAD). However, little is known about the association between CTR and immune‐related factors, including tumor‐infiltrating lymphocytes (TILs) density or tumor expression of programmed death ligand 1 (PD‐L1) and indoleamine 2,3‐dioxygenase 1 (IDO1) in small‐sized LAD. Methods This study included 258 patients with LAD ( 〈 3 cm) who underwent surgery. Patients were assigned to four groups: CTR = 0; 0  〈  CTR  〈 0.5; 0.5 ≤ CTR  〈 1 (ground‐glass opacity [GGO] group); and CTR = 1 (pure‐solid group). CD4 + , CD8 + , and FoxP3 + TIL density and PD‐L1 and IDO1 tumor expression were assessed by immunohistochemistry. Results Among the GGO group, CD8 + and FoxP3 + TIL density increased significantly with increasing CTR ( p   〈  0.001 and p   〈  0.001, respectively). Moreover, PD‐L1 and IDO1 expression was significantly higher in the pure‐solid group than in the GGO group ( p   〈  0.001 and p   〈  0.001, respectively). Conclusions CTR was correlated with the abundance of CD8 + and FoxP3 + TILs in the GGO group. PD‐L1 and IDO1 positivity rates were significantly higher in the pure‐solid group than in the GGO group. Increased CTR may be correlated with immunosuppressive condition.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v13.15
    DOI: 10.1111/1759-7714.14524
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2559245-2
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  • 4
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    Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor‐4 inhibition in hepatocellular carcinoma
    Wiley ; 2022
    In:  Cancer Science Vol. 113, No. 7 ( 2022-07), p. 2272-2287
    Details
    In: Cancer Science, Wiley, Vol. 113, No. 7 ( 2022-07), p. 2272-2287
    Abstract: The tyrosine kinase inhibitor lenvatinib is used to treat advanced hepatocellular carcinoma (HCC). Ferroptosis is a type of cell death characterized by the iron‐dependent accumulation of lethal lipid reactive oxygen species (ROS). Nuclear factor erythroid‐derived 2‐like 2 (Nrf2) protects HCC cells against ferroptosis. However, the mechanism of lenvatinib‐induced cytotoxicity and the relationships between lenvatinib resistance and Nrf2 are unclear. Thus, we investigated the relationship between lenvatinib and ferroptosis and clarified the involvement of Nrf2 in lenvatinib‐induced cytotoxicity. Cell viability, lipid ROS levels, and protein expression were measured using Hep3B and HuH7 cells treated with lenvatinib or erastin. We examined these variables after silencing fibroblast growth factor receptor‐4 (FGFR4) or Nrf2 and overexpressing‐Nrf2. We immunohistochemically evaluated FGFR4 expression in recurrent lesions after resection and clarified the relationship between FGFR4 expression and lenvatinib efficacy. Lenvatinib suppressed system X c − (xCT) and glutathione peroxidase 4 (GPX4) expression. Inhibition of the cystine import activity of xCT and GPX4 resulted in the accumulation of lipid ROS. Silencing‐FGFR4 suppressed xCT and GPX4 expression and increased lipid ROS levels. Nrf2‐silenced HCC cells displayed sensitivity to lenvatinib and high lipid ROS levels. In contrast, Nrf2‐overexpressing HCC cells displayed resistance to lenvatinib and low lipid ROS levels. The efficacy of lenvatinib was significantly lower in recurrent HCC lesions with low‐FGFR4 expression than in those with high‐FGFR4 expression. Patients with FGFR4‐positive HCC displayed significantly longer progression‐free survival than those with FGFR4‐negative HCC. Lenvatinib induced ferroptosis by inhibiting FGFR4. Nrf2 is involved in the sensitivity of HCC to lenvatinib.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.v113.7
    DOI: 10.1111/cas.15378
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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  • 5
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    Clinical effects of the use of the indocyanine green fluorescence imaging technique in laparoscopic partial liver resection
    Wiley ; 2022
    In:  Annals of Gastroenterological Surgery Vol. 6, No. 5 ( 2022-09), p. 688-694
    Details
    In: Annals of Gastroenterological Surgery, Wiley, Vol. 6, No. 5 ( 2022-09), p. 688-694
    Abstract: This study aimed to clarify the clinical effects of the indocyanine green (ICG)‐fluorescence imaging (FI) technique for determination of liver transection lines during laparoscopic partial liver resection for liver tumors. Methods This was a retrospective study including 112 patients who underwent laparoscopic partial liver resection for liver tumors. These enrolled patients were divided into an ICG‐FI group (n = 55) and a non‐ICG‐FI group (n = 57) according to the availability of the ICG‐FI. The clinicopathological characteristics of patients between two groups were compared before and after propensity score matching. Results The ICG‐FI and non‐ICG‐FI groups differed at baseline in terms of ICG retention rate at 15 min. After propensity score matching, two comparable groups of 32 patients each were obtained. The negativity rated of the pathological surgical margins were comparable between the two groups before and after propensity score matching. However, the surgical margins were significantly wider in the ICG‐FI group before and after propensity score matching ( P  = .039 and P  = .047, respectively). Conclusion The ICG‐fluorescence imaging technique may offer clinical benefits in terms of a secure surgical margin in laparoscopic partial liver resection.
    Type of Medium: Online Resource
    ISSN: 2475-0328 , 2475-0328
    URL: Issue
    URL: Article
    DOI: 10.1002/ags3.v6.5
    DOI: 10.1002/ags3.12563
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2895706-4
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  • 6
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    The ratio of serum des‐gamma‐carboxy prothrombin to tumor volume as a new biomarker for early recurrence of resected hepatocellular carcinoma
    Wiley ; 2022
    In:  Hepatology Research Vol. 52, No. 4 ( 2022-04), p. 381-389
    Details
    In: Hepatology Research, Wiley, Vol. 52, No. 4 ( 2022-04), p. 381-389
    Abstract: Early recurrence (ER) of hepatocellular carcinoma (HCC) (within 1 year after resection) is known to be a poor prognostic factor. The aim was to identify the risk factors associated with ER after HCC resection. Methods Data were analyzed retrospectively from patients who underwent primary resection for HCC from two hospitals. For cross‐validation, HCC resection cases were divided into the training and testing cohort. The clinicopathological factors between the ER and non‐ER groups and factors for predicting ER and prognosis after HCC resection were compared. Results Out of 173 patients in the training dataset, 33 patients had ER and the ER group showed larger tumor size, more intrahepatic metastasis (IM), and a higher ratio of serum des‐gamma‐carboxy prothrombin (DCP) to tumor volume (TV) (DCP/TV) than the non‐ER group. Out of 203 patients in the testing dataset, 30 patients had ER and the ER group demonstrated larger tumor size, more IM, and higher serum alpha‐fetoprotein, AFP/TV, DCP/TV, AFP/tumor maximum diameter (TMD), and DCP/TMD than the non‐ER group. The patients were divided into high and low DCP/TV groups and high serum DCP/TV was associated with unfavorable overall survival in the training and testing dataset. Multivariate analysis confirmed that high serum DCP/TV and IM were independently associated with ER. Conclusion Preoperative high serum DCP/TV may be useful for stratifying patients at risk of early HCC recurrence after curative resection.
    Type of Medium: Online Resource
    ISSN: 1386-6346 , 1872-034X
    URL: Issue
    URL: Article
    DOI: 10.1111/hepr.v52.4
    DOI: 10.1111/hepr.13750
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2006439-1
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  • 7
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    Impact and risk factors for skeletal muscle mass loss after hepatic resection in patients with hepatocellular carcinoma
    Wiley ; 2021
    In:  JGH Open Vol. 5, No. 7 ( 2021-07), p. 785-792
    Details
    In: JGH Open, Wiley, Vol. 5, No. 7 ( 2021-07), p. 785-792
    Abstract: The aims of this study were to determine whether a postoperative decrease in skeletal muscle mass (SMM) after hepatic resection can predict long‐term outcomes in patients with hepatocellular carcinoma (HCC) and identify risk factors for SMM loss in patients who undergo hepatic resection. Methods This was a large retrospective study of 400 patients who underwent hepatic resection for HCC and pre‐ and postoperative computed tomography (CT) scans. SMM was measured at the third lumbar vertebrae, and the postoperative change in SMM compared with preoperative values was calculated as Δ SMM. The cutoff value for the post‐/preoperative ratio was set at 0.9. Results Sixty patients (15.0%) developed SMM loss. These patients had a significantly prolonged prothrombin time ( P  = 0.0092), longer duration of surgery ( P  = 0.0021), more blood loss ( P  = 0.0040), and higher rate of postoperative complications ( P  = 0.0037) than those without SMM loss. Multivariate analysis revealed that prolonged prothrombin time and postoperative complications were independent risk factors for SMM loss after hepatic resection. Patients with SMM loss had significantly shorter overall survival ( P  = 0.0018) than the other patients had. SMM loss was an independent prognostic factor for overall survival (hazard ratio 1.551, 95% confidential interval 1.028–2.340, P  = 0.0363). Conclusions We demonstrated an association of SMM loss with postoperative complications and long‐term prognosis in patients with HCC. Patients with prolonged prothrombin time, or postoperative complications, may need to maintain their SMM. Further prospective studies are needed to investigate whether nutritional support can improve SMM loss.
    Type of Medium: Online Resource
    ISSN: 2397-9070 , 2397-9070
    URL: Issue
    URL: Article
    DOI: 10.1002/jgh3.v5.7
    DOI: 10.1002/jgh3.12588
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2919809-4
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