In:
Tumori Journal, SAGE Publications, Vol. 76, No. 3 ( 1990-06), p. 234-237
Abstract:
A combination of platinum (100 mg/m 2 in a 24-h continuous i.v. infusion) and mitomycin C (10 mg/m 2 i.v. push at the end of the cisplatin infusion) was administered in 20 patients with advanced breast cancer refractory to conventional treatments (CMF and anthracycline-containing regimens, hormonal therapies). The response rate was 20% (4/20), including one complete response of lung metastases which lasted 12 months. Median duration of partial responses was 4 months. Major toxicity was gastrointestinal and it was superimposable to that observed with other cisplatin-containing regimens. A marked and prolonged asthenia was reported in 6/20 patients (30%), and the regimen's compliance was poor. We conclude that at these doses and schedule, the cisplatin and mitomycin C combination has a limited efficacy in advanced breast cancer patients, and its use is not recommended in pretreated patients.
Type of Medium:
Online Resource
ISSN:
0300-8916
,
2038-2529
DOI:
10.1177/030089169007600305
Language:
English
Publisher:
SAGE Publications
Publication Date:
1990
detail.hit.zdb_id:
280962-X
detail.hit.zdb_id:
2267832-3
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