In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
Abstract:
Introduction: Acetaminophen-induced hypotension has been reported previously. It is uncertain whether acetaminophen directly impacts blood pressure and heart rate. Hypothesis: The meta-analysis investigates the effects of acetaminophen on the blood pressure and heart rate, and whether there is a dose-response relationship. Methods: This meta-analysis was conducted according to PRISMA guidelines. A search strategy was designed to utilize PubMed/Medline, EMBASE, and Google scholar for studies showing the effects of acetaminophen on blood pressure and heart rate from inception to February 20, 2022. After screening, 14 clinical trials were included in the analysis. Dichotomous data were pooled as relative risk (RR) and continuous data as mean difference (MD) or standardized mean difference (SMD) using the inverse-variance method. Heterogeneity was assessed using the Cochrane Q test, and its extent was determined by I-square (A value of more than 50% was considered a significant heterogeneity). Results: No statistically significant difference between acetaminophen and control for the overall effect on SBP (MD= -1.52, 95% CI = -4.66 to 1.61, p-value = 0.34) was observed. The findings remained consistent in subgroup analysis by dose, across one gram or less (p-value = 0.54), and more than one gram (p-value = 0.43). Similarly, no statistically significant difference was found for the overall effect on DBP (p-value = 0.61) although we found a statistically significant difference in DBP in the one gram or less subgroup (p-value = 0.02). Finally, we report no statistically significant difference between acetaminophen and control on the MAP (p-value = 0.32) and HR (p-value = 0.18). Conclusions: Acetaminophen has no significant effect on SBP, DBP, MAP, and HR. This effect is consistent with different doses except for a possible increase in DBP after using one gram or less. Further studies are needed to investigate the relevance of this effect.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.146.suppl_1.13251
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
detail.hit.zdb_id:
1466401-X
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