In:
Neuroepidemiology, S. Karger AG, Vol. 37, No. 1 ( 2011), p. 13-20
Abstract:
〈 i 〉 Background: 〈 /i 〉 Providing a valid and sensitive measure of different domains of cognitive performance in epidemiologic studies of early old-age populations presents a methodological challenge, given the broad range of variability in cognitive functioning in this age group. 〈 i 〉 Objectives: 〈 /i 〉 (1) To provide data on the distribution of cognitive performance scores in a representative sample of an early old-age population, and (2) to assess psychometric properties of a short cognitive performance measure developed within the framework of a cohort study. 〈 i 〉 Design: 〈 /i 〉 Population-based cohort study. 〈 i 〉 Setting and Participants: 〈 /i 〉 As part of the second examination of the Heinz Nixdorf Recall Study, 4,145 participants aged 50–80 years underwent a short cognitive performance assessment composed of 5 subtests with a mean duration of 7.31 min. Additionally, a subsample of 656 participants had a detailed neuropsychological and neurological examination. 〈 i 〉 Methods: 〈 /i 〉 Age- and education-specific cognitive performance scores in the total sample were calculated. Based on data from the subsample, concurrent validity was examined by comparing findings with a clinically validated neuropsychological assessment. 〈 i 〉 Results: 〈 /i 〉 In the total sample, younger and more highly educated participants had higher scores of cognitive performance. In the subsample, a good accuracy [area under the curve (AUC) = 0.81 (0.74–0.87)] of the short cognitive performance assessment compared with results from a clinically established Alzheimer disease assessment scale and diagnosis of mild cognitive impairment [AUC = 0.82 (0.78–0.82)] was observed. 〈 i 〉 Conclusion: 〈 /i 〉 This brief, cognitive performance measure, documenting good psychometric properties, can be useful in future epidemiological investigations exploring different domains and overall cognitive functioning in early old-age populations.
Type of Medium:
Online Resource
ISSN:
0251-5350
,
1423-0208
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
1483032-2
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