In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2021-1-7), p. e0243165-
Abstract:
Oxygen saturation (OS) imaging is a new method of endoscopic imaging that has clinical applications in oncology which can directly measure tissue oxygen saturation (Sto2) of the surface of gastrointestinal tract without any additional drugs or devices. This imaging technology is expected to contribute to research into cancer biology which leads to clinical benefit such as prediction to efficacy of chemotherapy or radiotherapy. However, adherent substances on tumors such as blood and white coating, pose a challenge for accurate measurements of the StO2 values in tumors. The aim of this study was to develop algorithms for discriminating between the tumors and their adherent substances, and to investigate whether it is possible to evaluate the tumor specific StO2 values excluding adherent substances during OS imaging. Methods We plotted areas of tumors and their adherent substances using white-light images of 50 upper digestive tumors: blood (68 plots); reddish tumor (83 plots); white coating (89 plots); and whitish tumor (79 plots). Scatter diagrams and discriminating algorithms using spectrum signal intensity values were constructed and verified using validation datasets. StO2 values were compared between the tumors and tumor adherent substances using OS images of gastrointestinal tumors. Results The discriminating algorithms and their accuracy rates (AR) were as follows: blood vs. reddish tumor: Y 〉 - 4.90X+7.13 (AR: 95.9%) and white coating vs. whitish tumor: Y 〈 -0.52X+0.17 (AR: 96.0%). The StO2 values (median, [range]) were as follows: blood, 79.3% [37.8%–100.0%] ; reddish tumor, 74.5% [62.0%–86.9%]; white coating, 73.8% [42.1%–100.0%] ; and whitish tumor, 65.7% [53.0%–76.3%]. Conclusions OS imaging is strongly influenced by adherent substances for evaluating the specific StO2 value of tumors; therefore, it is important to eliminate the information of adherent substances for clinical application of OS imaging.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0243165
DOI:
10.1371/journal.pone.0243165.g001
DOI:
10.1371/journal.pone.0243165.g002
DOI:
10.1371/journal.pone.0243165.g003
DOI:
10.1371/journal.pone.0243165.g004
DOI:
10.1371/journal.pone.0243165.g005
DOI:
10.1371/journal.pone.0243165.g006
DOI:
10.1371/journal.pone.0243165.g007
DOI:
10.1371/journal.pone.0243165.t001
DOI:
10.1371/journal.pone.0243165.t002
DOI:
10.1371/journal.pone.0243165.t003
DOI:
10.1371/journal.pone.0243165.t004
DOI:
10.1371/journal.pone.0243165.s001
DOI:
10.1371/journal.pone.0243165.s002
DOI:
10.1371/journal.pone.0243165.s003
DOI:
10.1371/journal.pone.0243165.r001
DOI:
10.1371/journal.pone.0243165.r002
DOI:
10.1371/journal.pone.0243165.r003
DOI:
10.1371/journal.pone.0243165.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
Permalink