In:
ChemMedChem, Wiley, Vol. 9, No. 8 ( 2014-08), p. 1775-1782
Abstract:
The photochemical properties and photodynamic activity of three porphyrazines (Pzs) containing annulated diazepine rings, including novel demetalated porphyrazine‐possessing bis(styryl)diazepine moieties were investigated. The porphyrazines were evaluated in terms of their electronic absorption and emission properties, their tendency to undergo aggregation and photodegradation, as well as their singlet oxygen generation efficiency. The in vitro photodynamic activity of the porphyrazines and their liposomal formulations were examined by using two oral squamous cell carcinoma cell lines. Magnesium(II) tribenzodiazepinoporphyrazine ( 1 ) revealed the highest phototoxic effect in both cell lines used, H413 and HSC‐3. Encapsulation of Pz 1 into L ‐α‐phosphatidyl‐ d,l ‐glycerol:1‐palmitoyl‐2‐oleoyl‐ sn ‐glycero‐3‐phosphocholine liposomes resulted in a nearly threefold increase in photocytotoxicity relative to that of the solution of Pz 1 (IC 50 values of 45 and 129 n M , respectively).
Type of Medium:
Online Resource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.201402085
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2209649-8
SSG:
15,3
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