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  • 1
    Online Resource
    Online Resource
    Public Library of Science (PLoS) ; 2012
    In:  PLoS ONE Vol. 7, No. 10 ( 2012-10-17), p. e47923-
    In: PLoS ONE, Public Library of Science (PLoS), Vol. 7, No. 10 ( 2012-10-17), p. e47923-
    Type of Medium: Online Resource
    ISSN: 1932-6203
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2012
    detail.hit.zdb_id: 2267670-3
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  • 2
    In: Zeitschrift für Geburtshilfe und Neonatologie, Georg Thieme Verlag KG, Vol. 224, No. 01 ( 2020-02), p. 15-21
    Abstract: Eine intrauterine Wachstumsrestriktion (IUGR) betrifft Feten, die ihr intrauterines Wachstumspotenzial nicht nutzen können. Überschneidungen bestehen dabei zur Gruppe der small-for-gestational age (SGA) Kinder, doch sind speziell IUGR-Kinder von kurz- und langfristigen Folgen betroffen. IUGR-Feten haben ein deutlich erhöhtes Frühgeburtlichkeits-Risiko und ein spezielles Risikoprofil im Vergleich zu altersentsprechend gewachsenen Frühgeborenen. Dies umfasst das häufigere Auftreten typischer Komplikationen wie Bronchopulmonale Dysplasie, intraventrikuläre Hämorrhagie und Mekonium-Ileus. Neugeborene mit IUGR scheinen langfristig ein erhöhtes Risiko für Folgeprobleme, wie Zerebralparesen, eingeschränkte Lungenfunktion und Sprachentwicklungsverzögerungen zu haben. Eine transsektorale, interdisziplinäre und multiprofessionelle Betreuung der Schwangeren, Neugeborenen und Säuglinge im Rahmen eines Versorgungspfades ist eine aussichtsreiche neue Versorgungsform. Sie umfasst die frühe Identifizierung von Schwangeren mit einem erhöhten Risiko für eine fetale Wachstumsrestriktion, ggf. die Therapie mit Acetylsalicylsäure, die Risiko-adaptierte Anbindung an die Perinatalzentren mit psychologischen Interventionen und neonatologischen Gesprächen. Ziel des Pfades ist die Vermeidung von Verlegungen in die Perinatologie und Totgeburten. Postnatal steht eine umfassende Betreuung mit besonderem Augenmerk auf die Eltern-Kind-Bindung und Ernährungsoptimierung im Mittelpunkt. Vertiefende Vorsorgeuntersuchungen der ambulanten Kinderärzte dienen dem frühen Aufdecken von Entwicklungsproblemen. Die Wirkungen, Akzeptanz und Kosteneffizienz dieses Pfades werden im Rahmen eines Projektes des Innovationsfonds getestet.
    Type of Medium: Online Resource
    ISSN: 0948-2393 , 1439-1651
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
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  • 3
    In: Acta Paediatrica, Wiley, Vol. 112, No. 8 ( 2023-08), p. 1653-1658
    Abstract: Whereas there is agreement that surfactant should be administered without mechanical ventilation, there is still a debate concerning the optimal method. DD‐SURF combines the benefits of INSURE and less invasive surfactant administration (LISA). The efficacy of this approach has not been evaluated yet. Methods Retrospective cohort study of all preterm newborns below 30 0/7 weeks gestational age admitted to the neonatal intensive care unit. Data on surfactant therapy, respiratory support during the first 96 h of life and neonatal morbidities until hospital discharge were collected from the electronic patient charts to evaluate the efficacy and safety of our approach. Results In total, 222 newborns met the inclusion criteria; 174 (78%) received surfactant in the delivery room by the DD‐SURF procedure and 21 infants (10%) were not extubated after surfactant administration (Surf‐and‐vent group). After DD‐SURF, 75% of patients did not require reintubation. Intraventricular haemorrhage and bronchopulmonary dysplasia occured more often in infants after DD‐SURF failure than after successful DD‐SURF. Conclusion DD‐SURF potentially combines the benefits of INSURE and LISA and represents a useful alternative of surfactant delivery with comparable success rates to thin‐catheter surfactant administration.
    Type of Medium: Online Resource
    ISSN: 0803-5253 , 1651-2227
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1492629-5
    detail.hit.zdb_id: 1501466-6
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  • 4
    Online Resource
    Online Resource
    MDPI AG ; 2021
    In:  International Journal of Environmental Research and Public Health Vol. 18, No. 8 ( 2021-04-14), p. 4140-
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 18, No. 8 ( 2021-04-14), p. 4140-
    Abstract: Early nutrition of newborns significantly influences their long-term health. Mother’s own milk (MOM) feeding lowers the incidence of complications in preterm infants and improves long-term health. Unfortunately, prematurity raises barriers for the initiation of MOM feeding and its continuation. Mother and child are separated in most institutions, sucking and swallowing is immature, and respiratory support hinders breastfeeding. As part of a quality-improvement project, we review the published evidence on risk factors of sustained MOM feeding in preterm neonates. Modifiable factors such as timing of skin-to-skin contact, strategies of milk expression, and infant feeding or mode of delivery have been described. Other factors such as gestational age or neonatal complications are unmodifiable, but their recognition allows targeted interventions to improve MOM feeding. All preterm newborns below 34 weeks gestational age discharged over a two-year period from our large German level III neonatal center were reviewed to compare institutional data with the published evidence regarding MOM feeding at discharge from hospital. Based on local data, a risk score for non-MOM feeding can be calculated that helps to identify mother–baby dyads at risk of non-MOM feeding.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2175195-X
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  • 5
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  BMC Pediatrics Vol. 22, No. 1 ( 2022-12)
    In: BMC Pediatrics, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: In preterm infants with premature rupture of membranes, antibiotic treatment is frequently started but rates of early onset sepsis are lower. In line with national guidelines, a stratified approach in the decision to start antibiotic treatment using maternal history, clinical impression and biomarkers has been implemented in our level III neonatal center and its results are evaluated. Methods Retrospective cohort study of all preterm newborns with rupture of membranes at least 1 h prior to delivery admitted to our tertiary neonatal intensive care unit. Data on antibiotic exposure, mortality and major neonatal complications were extracted from the electronic patient charts to evaluate the effects and safety of our stratified approach. Results Four hundred fifty-six infants met the inclusion criteria. 120 (26%) received primary antibiotics whereas 336 (74%) did not. Of those receiving primary antibiotics, 13 (11%) had a blood culture positive sepsis, 46 (38%) met the criteria of clinical sepsis and in 61 (51%) sepsis was ruled out and antibiotics were stopped after 48-96 h. All infants with blood culture positive sepsis were identified and treated within the first 24 h of life using this approach. None of the 336 infants who were not started on antibiotics primarily needed antibiotic therapy within the first 5 days of life. There were no deaths or major neonatal complications in the group that did not receive empiric antibiotics. Conclusions Our stratified approach for preterm infants with premature rupture of membranes allows a safe reduction of antibiotic exposure even in this high risk population. As a result, only 25% of high risk preterm newborns are treated with antibiotics of which more than half receive less than 5 days of treatment. To treat one infant with blood culture positive sepsis, only 9 infants receive empiric antibiotics.
    Type of Medium: Online Resource
    ISSN: 1471-2431
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041342-7
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  • 6
    In: Archives of Disease in Childhood - Fetal and Neonatal Edition, BMJ, Vol. 107, No. 4 ( 2022-07), p. 454-456
    Type of Medium: Online Resource
    ISSN: 1359-2998 , 1468-2052
    Language: English
    Publisher: BMJ
    Publication Date: 2022
    detail.hit.zdb_id: 2188490-0
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  • 7
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2018
    In:  Neonatologie Scan Vol. 07, No. 04 ( 2018-12), p. 273-286
    In: Neonatologie Scan, Georg Thieme Verlag KG, Vol. 07, No. 04 ( 2018-12), p. 273-286
    Type of Medium: Online Resource
    ISSN: 2194-5462 , 2194-5470
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
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  • 8
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Pediatrics Vol. 10 ( 2023-1-9)
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 10 ( 2023-1-9)
    Abstract: Around 140 million children are born every year and post-natal transition is uncomplicated in the vast majority. However, around 5%–15% of neonates receive supportive interventions during transition. Recent data on the interventions used is scarce. More data on the frequencies with which these interventions are used is needed to evaluate neonatal resuscitation, guide recommendations and to generate hypotheses for further research. The following protocol describes an international, multicentre survey on the interventions currently applied during neonatal resuscitation. Objectives To determine the frequencies at which different supportive interventions recommended by European Resuscitation Council (ERC) guidelines for neonatal resuscitation are used. To compare the frequencies between hospitals and patient groups and to investigate possible factors influencing any differences found. Methods Participating hospitals will collect data on all interventions performed during neonatal resuscitation over a period of 6 months. All hospitals providing perinatal care are eligible regardless of size and designated level of neonatal care. Every neonate requiring more interventions than basic drying and tactile stimulation during the first 30 min of life will be included. The targeted sample size is at least 4,000 neonates who receive interventions. After anonymization, the data is pooled in a common database and descriptive and statistical analysis is performed globally and in subgroups. Possible correlations will be investigated with phi coefficient and chi square testing. Ethics and dissemination Consent of the institutional review board of the Technical University Dresden was obtained for the local data collection under the number BO-EK-198042022. Additionally, approval of local ethical or institutional review boards will be obtained by the participating hospitals if required. Results will be published in peer-reviewed journals and presented at suitable scientific conferences.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711999-3
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  • 9
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Pediatrics Vol. 9 ( 2021-5-28)
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 9 ( 2021-5-28)
    Abstract: Background: Postnatal brain growth is an important predictor of neurodevelopmental outcome in preterm infants. A new reliable proxy for brain volume is cranial volume, which can be measured routinely by 3-D laser scanning. The aim of this study was to develop reference charts for normal cranial volume in newborn infants at different gestational ages starting from late preterm for both sexes. Methods: Cross-sectional cohort study in a German university hospital, including singleton, clinically stable, neonates born after 34 weeks of gestation. Cranial volume was measured in the first week of life by a validated 3-D laser scanner. Cranial volume data was modeled to calculate percentile values by gestational age and birth weight and to develop cranial volume reference charts for girls and boys separately. Results: Of the 1,703 included infants, 846 (50%) were female. Birth weights ranged from 1,370 to 4,830 grams (median 3,370). Median cranial volume ranged from 320 [interquartile range (IQR) 294–347] ml at 34 weeks to 469 [IQR 442–496] ml at 42 weeks and was higher in boys than in girls. Conclusions: This study presents the first reference charts of cranial volume which can be used in clinical practice to monitor brain growth between 34 and 42 weeks gestation in infants.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2711999-3
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  • 10
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Advances in Neonatal Care Vol. 22, No. 4 ( 2022-08), p. 357-361
    In: Advances in Neonatal Care, Ovid Technologies (Wolters Kluwer Health), Vol. 22, No. 4 ( 2022-08), p. 357-361
    Abstract: Arterial catheterization is a routine procedure in extremely preterm neonates. Umbilical arterial catheters (UACs) are typically used for this purpose, but life-threatening complications have been described. Peripheral arterial lines (PALs) might offer a valuable alternative, but their feasibility in extremely preterm newborns is unclear. Purpose: To investigate efficacy and complications of PALs in extremely preterm neonates. Methods: Retrospective analysis of patients born below 26 weeks of gestation in 2011-2014 (cohort 1, UAC as primary arterial access) and 2015-2019 (cohort 2, PAL as primary arterial access). Arterial line placement during their first 14 days of life, duration of arterial access, reasons for discontinuation, and long-term complications were recorded from health records. Results: In total, 161 of 202 newborns had an arterial line during their first 14 days of life. In cohort 2, the life span of a PAL was significantly longer than that in cohort 1. Signs of dysfunction were the primary reason to discontinue a PAL. Signs of peripheral ischemia were present in 36 of 105 cases (34%) when the PAL was removed but persisted in only 2 patients. UAC-associated persistent ischemic damage occurred in 2 of 97 patients. Implications for Practice and Research: PALs are a valuable alternative to UACs even in preterm newborns below 26 weeks of gestational age. A special focus on ischemic complications is warranted. Prospective, multicenter studies to verify safety and efficacy of arterial line management and complications in extremely preterm infants are warranted.
    Type of Medium: Online Resource
    ISSN: 1536-0903
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
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