In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 131, No. 4_Supplement ( 2012-04-01), p. 3339-3339
Abstract:
Programmable microfluidic systems for bioparticles manipulation that could enable automated biological analysis and diagnostics have the potential to revolutionize a wide range of applications in life sciences research, clinical diagnostics, and drug discovery. Several methods such as those based on hydrodynamic force, magnetic tweezers, and dielectrophoresis can manipulate the movement of the bioparticles successfully. However, these methods must be constructed the flow structure, magnetic wire, and electrode in the microchannel respectively, which not only limits the flexibility of manipulation but also makes the sample more likely to be contaminated. In this paper, a programmable microfluidic device is developed to manipulate the microbubbles along an arbitrary trajectory in the microchannel without any structure by introducing phase-shifts to a planar standing surface acoustic wave field. The microbubbles can be transported in a square trajectory, circular trajectory and even helix trajectory via adjusting the relative phase between the excitation signals controlled by LabVIEW program. The results reveal that the microbubbles can be transported over a predetermined distance continuously until they reach the targeted locations. This acoustic programmable microfluidic device would have potential applications on drug screening, cell studies, and other biomedical applications.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2012
detail.hit.zdb_id:
1461063-2
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