In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 6, No. 1 ( 1999-01), p. 29-69
Abstract:
lndolo[2,3-a]carbazoles, their pyrrolo[3,4-c] anellated variants and structurally closely related bisindolylmaleimides represent a biologically highly interesting class of natural compounds which are potential anticancer agents. According to the ongoing literature new and efficient synthetic methods yield a great variety of these compounds which have been reported
in detail. The biological activities and the inhibitory activities against the target enzymes protein kinase C and topoisomerase I are also discussed including structure activity relationships. A molecular binding model of the protein kinase C inhibitors with the target enzyme at the atomic level is presented and supported by X-ray crystallographic structures and by molecular modelling studies.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0929867306666220207210053
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
1999
SSG:
15,3
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