In:
EMBO Molecular Medicine, EMBO, Vol. 9, No. 9 ( 2017-09), p. 1314-1325
Abstract:
image To transmit between humans, zoonotic viruses need to acquire human‐type receptor specificity. Analyzing the effects of different amino acid mutations in the receptor binding site revealed that H6 HA only requires a single amino acid mutation to specifically adapt to human‐type receptor binding. G225D in H6 HA confers human‐type receptor binding. H6‐G225D lost binding to chicken and gained binding to human airway tissues. Structural analyses show classic human‐type receptor binding. H6 G225D still maintains low thermostability and is thus not yet fully adapted to transmit between humans.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201707726
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
2485479-7
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