In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 111, No. 5_Supplement ( 2002-05-01), p. 2462-2462
Abstract:
Gas-based contrast agents are known to increase ultrasound-induced bioeffects, presumably via an inertial cavitation (IC) mechanism. The relationship between IC ‘‘dose’’ (ICD) (cumulated rms broadband noise amplitude in the frequency domain) and 1.1-MHz ultrasound-induced hemolysis in whole human blood was explored with additions of Optison or degassed saline; the hypothesis was that hemolysis would correlate with ICD. Four experimental series were conducted, with variable: (1) peak negative acoustic pressure [P−]; (2) Optison concentration; (3) pulse duration; and (4) total exposure duration and variable Optison concentration. The P– thresholds for hemolysis and ICD above noise levels were ∼0.5 MPa. Enhancement of ICD and hemolysis was detected even at the lowest Optison concentration tested (0.1%) at P−=3 MPa. At 2 MPa P–(0.3% Optison), significant hemolysis and ICD were detected with pulse durations as brief as 2 and 4 cycles, respectively. At 3 MPa P–, hemolysis and ICD evolved as functions of time and Optison concentration; ultimate levels of hemolysis and ICD depended strongly on initial Optison concentration, but initial rates of change did not. Within experimental series, hemolysis was significantly correlated with ICD; across series, the correlation was significant at p less than 0.001.
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2002
detail.hit.zdb_id:
1461063-2
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