In:
FEBS Letters, Wiley, Vol. 593, No. 4 ( 2019-02), p. 423-432
Kurzfassung:
Glucocorticoids have various medical uses but are accompanied by side effects. The glucocorticoid receptor ( GR ) has been reported to regulate the clock genes, but the underlying mechanisms are incompletely understood. In this study, we focused on the suppressive effect of the GR on the expression of Rev‐erbα (Nr1d1), an important component of the clock regulatory circuits. Here we show that the GR suppresses Rev‐erbα expression via the formation of a complex with CLOCK and BMAL 1, which binds to the E‐boxes in the Nr1d1 promoter. In this GR ‐ CLOCK ‐ BMAL 1 complex, the GR does not directly bind to DNA , which is referred to as tethering. These findings provide new insights into the role of the GR in the control of circadian rhythm.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.2019.593.issue-4
DOI:
10.1002/1873-3468.13328
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
1460391-3
SSG:
12
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