In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2022-7-8), p. e0269550-
Abstract:
The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. Methods We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. Results During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality ( P 〈 0.05). Conclusion MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0269550
DOI:
10.1371/journal.pone.0269550.g001
DOI:
10.1371/journal.pone.0269550.t001
DOI:
10.1371/journal.pone.0269550.t002
DOI:
10.1371/journal.pone.0269550.t003
DOI:
10.1371/journal.pone.0269550.t004
DOI:
10.1371/journal.pone.0269550.t005
DOI:
10.1371/journal.pone.0269550.s001
DOI:
10.1371/journal.pone.0269550.s002
DOI:
10.1371/journal.pone.0269550.s003
DOI:
10.1371/journal.pone.0269550.r001
DOI:
10.1371/journal.pone.0269550.r002
DOI:
10.1371/journal.pone.0269550.r003
DOI:
10.1371/journal.pone.0269550.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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