In:
International Journal of Cancer, Wiley, Vol. 135, No. 4 ( 2014-08-15), p. 948-955
Abstract:
What's new? An estimated 35% of colorectal cancer (CRC) risk may be due to inherited factors, about 10% of which have been identified in genome‐wide association studies (GWAS), though those studies have focused mainly on populations of European ancestry. This GWAS of CRC focused on individuals of East Asian ancestry, with SNP rs7229639 in the SMAD7 gene found to be associated with CRC risk, independent of rs4939827, which was reported previously in a European population. The findings highlight the role of SMAD7 in the etiology of CRC and suggest that genetic risk variants may differ by study populations.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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