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  • 1
    Online Resource
    Online Resource
    Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
    Walter de Gruyter GmbH ; 2016
    In:  Journal of Pediatric Endocrinology and Metabolism Vol. 29, No. 12 ( 2016-01-1)
    Details
    In: Journal of Pediatric Endocrinology and Metabolism, Walter de Gruyter GmbH, Vol. 29, No. 12 ( 2016-01-1)
    Abstract: Vitamin D deficiency is a widely recognized public health problem. Efficacy of a recently developed micellized form of vitamin D3 has not been studied. Hence, we undertook this study to compare its efficacy with the conventionally used fat-soluble vitamin D3. Methods: In this open-labeled nonrandomized pilot study, we recruited 180 healthy children, aged 13–14 years in two groups and supplemented Group A (60 children) with 60,000 IU of fat-soluble vitamin D3/month with milk and Group B (120 children) with 60,000 IU/month of water miscible vitamin D3 under supervision for 6 months. Serum 25(OD)D, parathyroid hormone (PTH), calcium, phosphate, and alkaline phosphatase (ALP) levels were evaluated before and after supplementation in 156 children (54 in Group A and 102 in Group B) who completed the study. Results: We observed a significantly greater increase in the serum 25(OH)D levels in group B as compared to group A (31.8±9.1 ng/mL vs. 23.7±10.4 ng/mL; p 〈 0.001). All children in group B achieved adequate levels of serum 25(OH)D ( 〉 20 ng/mL) as against 83.3% children in group A. Serum PTH and ALP levels declined considerably in both the groups following supplementation. Conclusions: Vitamin D supplementation significantly increased the serum 25(OH)D levels in both groups. Miscible form of vitamin D3 appears to be better in achieving higher levels of serum 25(OH)D than that observed with a similar dose of fat-soluble vitamin D3. Further studies with different dose regimens are required to establish its efficacy over the conventionally used fat-soluble vitamin D3.
    Type of Medium: Online Resource
    ISSN: 2191-0251 , 0334-018X
    URL: Article
    DOI: 10.1515/jpem-2016-0191
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2583847-7
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  • 2
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    A randomised controlled trial comparing the efficacy of micellised and fat-soluble vitamin D 3 supplementation in healthy adults
    Cambridge University Press (CUP) ; 2019
    In:  British Journal of Nutrition Vol. 121, No. 8 ( 2019-04-28), p. 859-865
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 121, No. 8 ( 2019-04-28), p. 859-865
    Abstract: Nanoemulsion formulation of vitamin D 3 have been shown to have better bioavailability than the coarse emulsion preparation in vitro and in vivo animal studies. In the absence of randomised trial in humans, comparing the efficacy of nanotechnology-based miscellised vitamin D 3 over conventional vitamin D 3 , we undertook this study. A total of 180 healthy adults were randomised to receive either micellised (DePura, group A) or conventional vitamin D 3 (Calcirol, group B) at a monthly dose of 60 000 IU (1500μg) for 6 months. The outcome parameters were serum 25 - hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), Ca, phosphate, alkaline phosphatase and urinary Ca:creatinine ratio. A total of eighty-nine subjects in group A and seventy-seven in group B completed the trial. Subjects in both the groups had a significant increase in their serum 25(OH)D levels following supplementation (group A: 21·5 ( sd 10·9) to 76·7 ( sd 18·8) nmol/l ( P 〈 0·001); group B: 22·8 ( sd 10·4) to 57·8 ( sd 16·0) nmol/l ( P 〈 0·001)). Participants in micellised group had an additional increase of 20·2 (95 % CI 14·0, 26·4) nmol/l in serum 25(OH)D levels ( P 〈 0·001). The difference between the groups was 17·5 (95 % CI 11·8, 23·1) nmol/l, which remained statistically significant ( P 〈 0·001) even after adjustment for age and sex. Significant decline in mean serum PTH was observed in both the groups. No hypercalcaemia or hypercalciuria was noted. Although supplementation with both the preparations resulted in a significant rise in serum 25(OH)D levels, micellised vitamin D 3 appeared to be more efficacious in achieving higher levels of serum 25(OH)D.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1017/S0007114518003215
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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  • 3
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    Impact of three different daily doses of vitamin D 3 supplementation in healthy schoolchildren and adolescents from North India: a single-blind prospective randomised clinical trial
    Cambridge University Press (CUP) ; 2019
    In:  British Journal of Nutrition Vol. 121, No. 5 ( 2019-03-14), p. 538-548
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 121, No. 5 ( 2019-03-14), p. 538-548
    Abstract: In India, there is a lack of information about the adequate daily dose of vitamin D 3 supplementation in school children. Hence, we undertook this study to evaluate the adequacy and efficacy of different doses of vitamin D 3 in schoolchildren. A total of 1008 vitamin D-deficient (VDD) children, aged 6–16 years with serum 25-hydroxyvitamin D (25(OH)D) levels 〈 50nmol/l, were cluster randomised into three groups (A-344, B-341 and C-232) for supplementation (600, 1000 and 2000 IU daily) of vitamin D 3 under supervision for 6 months. Of the 1008 subjects who completed the study, 938 (93 %) were compliant. Baseline and post-supplementation fasting blood and urine samples were evaluated for Ca, phosphates, alkaline phosphatase, 25(OH)D and parathormone and urine Ca:creatinine ratio. The mean age of the subjects was 11·7 ( sd 2·4) years, and the overall mean baseline serum 25(OH)D level was 24·3 ( SD 9·5)nmol/l. Post-supplementation rise in serum 25(OH)D in compliant group was maximum with 2000 IU (70·0 ( SD 30·0)nmol/l), followed by 1000 IU (46·8 ( SD 22·5)nmol/l) and 600 IU (36·5 ( SD 18·5)nmol/l), and serum 25(OH)D levels of ≥50nmol/l were achieved in 71·5, 81·8 and 92·9 % by groups A, B and C, respectively. Secondary hyperparathyroidism decreased from 31·7 to 8·4 % post-supplementation. Two participants developed hypercalciuria, but none developed hypercalcaemia. Children with VDD benefit maximum with the daily supplementation of 2000 IU of vitamin D 3 . Whether recommendations of 400 IU/d by Indian Council of Medical Research or 600 IU by Indian Academy of Pediatrics or Institute of Medicine would suffice to achieve vitamin D sufficiency in children with VDD remains debatable.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1017/S0007114518003690
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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