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  • 1
    In: Texas Heart Institute Journal, Texas Heart Institute Journal, Vol. 44, No. 4 ( 2017-08-01), p. 252-259
    Abstract: Using cardiac magnetic resonance, we tested whether a single-breath-hold approach to cardiac functional evaluation was equivalent to the established multiple-breath-hold method. We examined 39 healthy volunteers (mean age, 31.9 ± 11.4 yr; 22 men) by using 1.5 T with multiple breath-holds and our proposed single breath-hold. Left ventricular and right ventricular ejection fractions (LVEF and RVEF), LV and RV end-diastolic volumes (LVEDV and RVEDV), and LV myocardial mass (LVMM) were compared by using Bland-Altman plots; LVEF and RVEF were tested for equivalence by inclusion of 95% confidence intervals (CIs). Equivalence of the methods was assumed within the range of −5% to 5%. In the multiple- versus the single-breath-hold method, LVEF was 0.62 ± 0.05 versus 0.62 ± 0.04, and RVEF was 0.59 ± 0.06 versus 0.59 ± 0.07. The mean difference in both methods was −0.2% (95% CI, −1 to 0.6) for LVEF and 0.3% (95% CI, −0.8 to 1.5) for RVEF. The mean differences between methods fit within the predetermined range of equivalence, including the 95% CI. The mean relative differences between the methods were 3.8% for LVEDV, 4.5% for RVEDV, and 1.6% for LVMM. Results of our single-breath-hold method to evaluate LVEF and RVEF were equivalent to those of the multiple-breath-hold technique. In addition, LVEDV, RVEDV, and LVMM showed low bias between methods.
    Type of Medium: Online Resource
    ISSN: 0730-2347 , 1526-6702
    Language: English
    Publisher: Texas Heart Institute Journal
    Publication Date: 2017
    detail.hit.zdb_id: 2068440-X
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  • 2
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 44, No. 1 ( 2016-07), p. 186-193
    Abstract: To introduce a dual‐contrast fast spin‐echo (dcFSE) sequence for signal decay mapping of myocardial edema. Materials and Methods After consultation with the Institutional Review Board, 22 acute myocardial infarction (MI) patients were examined with magnetic resonance imaging (MRI) at 1.5T 2 days after revascularization. Edema was evaluated in 16 myocardial segments with an exponential fit for signal decay time (SDT) in dcFSE mapping and T 2 signal intensity ratio for single‐contrast FSE. Myocardial viability was evaluated in late gadolinium enhancement (LGE). A control group of 10 volunteers was examined for edema imaging. SDT was compared in segment groups: 1) with LGE in MI, 2) penumbra, 3) remote from LGE, 4) controls. Groups 1/3 and 3/4 were tested on difference. Three phantoms providing similar T 2 but different T 1 relaxation times (low, intermediate, high) were examined with dcFSE and multicontrast spin echo sequence as a reference. Results The SDT/ T 2 ratio for segment groups was 1) 82msec/1.7 in segments with LGE; 2) 65msec/1.6 for penumbra, 3) 62msec/1.7 for remote segments, and 4) 50msec/1.6 in controls. In dcFSE group 1/3 ( P 〈 0.0001) and in group 3/4 ( P  = 0.0002) SDT was significantly different. In single‐contrast FSE the T 2 ratio was not significantly different for both tests: 1/3 P  = 0.1889; 3/4 P  = 0.8879. T 2 ‐overestimation of dcFSE was 23% in low, 29% in intermediate, and 35% in highly T 1 contaminated phantoms. Conclusion dcFSE signal decay edema mapping is feasible in volunteers and patients. DcFSE SDT is superior to T 2 ratio for detection of high‐grade and diffuse myocardial edema. J. Magn. Reson. Imaging 2016;44:186–193.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1497154-9
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