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  • Wiley  (2)
  • Martins, Pedro  (2)
  • 1
    Online Resource
    Online Resource
    Wiley ; 2014
    In:  International Journal for Numerical Methods in Biomedical Engineering Vol. 30, No. 12 ( 2014-12), p. 1409-1420
    In: International Journal for Numerical Methods in Biomedical Engineering, Wiley, Vol. 30, No. 12 ( 2014-12), p. 1409-1420
    Abstract: Hearing is a sequence of processes in which the ear translates sound waves into electrical signals, which are then sent to the brain where they are interpreted as sound. The ossicular chain of the middle ear is formed by three ossicles (malleus, incus, and stapes), of which the last and smallest, the stapes, vibrates, thus communicating with the inner ear through the stapes footplate. When abnormal bone formation immobilizes the stapes (otosclerosis), the passage of sound does not correctly occur and hearing can be compromised. In most cases, surgery is an option for its treatment. The stapes is totally or partially replaced by a prosthesis (stapedectomy or stapedotomy, respectively) allowing the passage of sound to the inner ear. This work presents a study on the behavior of different stapes prostheses, considering their biomechanical characteristics. The stapes was replaced by different prostheses, made of dissimilar materials: stainless steel, teflon, and titanium. The umbo and stapes footplate displacements for the models with these prostheses were obtained and compared with the displacements obtained with the model representative of the normal ear. In the models with prostheses, the displacements are found in the hole where the prosthesis is attached. Copyright © 2014 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 2040-7939 , 2040-7947
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2540968-2
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  • 2
    In: Advanced Healthcare Materials, Wiley, Vol. 5, No. 23 ( 2016-12), p. 3027-3034
    Abstract: A drug release system is developed capable to modulate the drug release kinetics by the application of a magnetic field. Thus, this work reports on the production, characterization, and release kinetics of a poly( l ‐lactic acid) (PLLA) microporous membrane containing a zeolite (Faujasite) and a magnetic stimuli‐sensitive component, magnetostrictive Terfenol‐D (TD), for the release of ibuprofen (IBU) as drug model. For membranes containing IBU‐loaded zeolites and TD without an applied AC magnetic field, the release kinetics is characterized by a first order release. On the other hand, the application of an AC magnetic field modifies the release profile of the membrane, leading to an increase of the release rate by more than 30%, the magnetically driven release being characterized by a super case‐II within the Korsmeyer–Peppas model, indicating a release mainly driven by a swelling or erosion mechanism, induced by the magnetostrictive particles under the applied magnetic field. The increase of the TD w/w from 10% to 20% has as a consequence a decrease in the quantity of IBU released from 79% to 70%; on the contrary, increasing the H AC intensity from 100 to 200 mT promotes an increase on the percentage of IBU released from 67% to 75%.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2645585-7
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