In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 75, No. 2 ( 2013), p. 85-92
Abstract:
〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 To compare biomechanical properties of vaginal tissues between women with and without pelvic organ prolapse (POP) and investigate factors that may influence these properties. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Forty patients submitted to POP surgery and 15 non-POP cadavers were evaluated. The tissue was excised from anterior and posterior middle third vagina. The biomechanical properties considered were stiffness (E) and maximum stress (S 〈 sub 〉 max 〈 /sub 〉 ), and they were evaluated by means of uniaxial tension tests. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 POP patients were associated with higher values of E (13.1 ± 0.8 vs. 9.5 ± 0.7 MPa; p 〈 0.001) and S 〈 sub 〉 max 〈 /sub 〉 (5.3 ± 0.5 vs. 3.2 ± 0.9 MPa; p 〈 0.001) in the anterior vaginal wall compared to the posterior wall. In contrast, non-POP women presented lower values of E (6.9 ± 1.1 vs. 10.5 ± 1.0 MPa; p = 0.01) and S 〈 sub 〉 max 〈 /sub 〉 (2.6 ± 0.4 vs. 3.5 ± 0.4 MPa; p = 0.043) in the anterior wall. The occurrence of POP was the only independent predictor of higher values of E and S 〈 sub 〉 max 〈 /sub 〉 in anterior vaginal samples (p = 0.003 and p = 0.008, respectively). Women with severe anterior vaginal prolapse presented higher levels of E and S 〈 sub 〉 max 〈 /sub 〉 in the anterior sample compared to those with lower POP stages (p = 0.001 and p = 0.01; respectively). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Women with POP present significant changes of biomechanical properties in the vagina.
Type of Medium:
Online Resource
ISSN:
0378-7346
,
1423-002X
Language:
English
Publisher:
S. Karger AG
Publication Date:
2013
detail.hit.zdb_id:
1482695-1
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