In:
Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 4, No. 10 ( 2015-10-27)
Abstract:
Patients with dilated cardiomyopathy ( DCM ) may present with ventricular arrhythmias early in the disease course, unrelated to the severity of left ventricular dysfunction. These patients may be classified as having an arrhythmogenic DCM ( AR ‐ DCM ). We investigated the phenotype and natural history of patients with AR ‐ DCM . Methods and Results Two hundred eighty‐five patients with a recent diagnosis of DCM (median duration of the disease 1 month, range 0 to 7 months) and who had Holter monitoring at baseline were comprehensively evaluated and followed for 107 months (range 29 to 170 months). AR ‐ DCM was defined by the presence of ≥1 of the following: unexplained syncope, rapid nonsustained ventricular tachycardia (≥5 beats, ≥150 bpm), ≥1000 premature ventricular contractions/24 hours, and ≥50 ventricular couplets/24 hours, in the absence of overt heart failure. The primary end points were sudden cardiac death ( SCD ), sustained ventricular tachycardia ( SVT ), or ventricular fibrillation ( VF ). The secondary end points were death from congestive heart failure or heart transplantation. Of the 285 patients, 109 (38.2%) met criteria for AR ‐ DCM phenotype. AR ‐ DCM subjects had a higher incidence of SCD / SVT / VF compared with non– AR ‐ DCM patients (30.3% vs 17.6%, P =0.022), with no difference in the secondary end points. A family history of SCD / SVT / VF and the AR ‐ DCM phenotype were statistically significant and cumulative predictors of SCD / SVT / VF . Conclusions One‐third of DCM patients may have an arrhythmogenic phenotype associated with increased risk of arrhythmias during follow‐up. A family history of ventricular arrhythmias in DCM predicts a poor prognosis and increased risk of SCD .
Type of Medium:
Online Resource
ISSN:
2047-9980
DOI:
10.1161/JAHA.115.002149
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2015
detail.hit.zdb_id:
2653953-6
Permalink