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  • 1
    Online Resource
    Online Resource
    The safety and efficacy of short‐term budesonide delivered via mucosal atomization device for chronic rhinosinusitis without nasal polyposis
    Wiley ; 2014
    In:  International Forum of Allergy & Rhinology Vol. 4, No. 5 ( 2014-05), p. 397-402
    Details
    In: International Forum of Allergy & Rhinology, Wiley, Vol. 4, No. 5 ( 2014-05), p. 397-402
    Abstract: Budesonide is a potent corticosteroid commonly prescribed for management of inflammation in chronic rhinosinusitis (CRS). The standard for prescribing budesonide is via impregnated nasal saline irrigation (INSI), although recently the mucosal atomization device (MAD) has emerged as a theoretically superior method of distributing medication into the sinuses. The MAD atomizes medication into small droplets and this is thought to enhance absorption and improve bioavailability. However, no studies have shown whether enhanced absorption and improved bioavailability of budesonide via MAD causes adrenal suppression. The objective of this study is to determine whether budesonide via MAD affects the hypothalamic‐pituitary‐adrenal (HPA) axis. Methods Twenty CRS patients were recruited from a tertiary rhinology clinic and randomized to take budesonide (1 mg) via MAD or via INSI twice a day for 60 days. The adrenocorticotropic hormone (ACTH) stimulation test and 22‐item Sinonasal Outcomes Test (SNOT‐22) questionnaire were administered on days 1, 30, and 60 of the study. Plasma budesonide and cortisol levels were simultaneously quantified using a high‐performance liquid chromatography–tandem mass spectrometry technique. Results There was no indication of adrenal suppression in either group (n = 20) based on ACTH stimulation test results nor was there significant plasma budesonide levels detected in either group. Quality of life, as indicated by SNOT‐22, did not differ between groups at 60 days ( p = 0.404; 95% confidence interval [CI], −37.2 to 15.9), but SNOT‐22 scores for patients using MAD did show statistically significant improvement at 60 days compared to baseline ( p = 0.02). Conclusion The MAD is likely a safe and effective method of delivering budesonide to the sinuses in the short term.
    Type of Medium: Online Resource
    ISSN: 2042-6976 , 2042-6984
    URL: Issue
    URL: Article
    DOI: 10.1002/alr.2014.4.issue-5
    DOI: 10.1002/alr.21280
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2604059-1
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  • 2
    Online Resource
    Online Resource
    Sarcopenia, Cerebral Palsy, and Botulinum Toxin Type A
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  JBJS Reviews Vol. 7, No. 8 ( 2019-8-15), p. e4-e4
    Details
    In: JBJS Reviews, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 8 ( 2019-8-15), p. e4-e4
    Abstract: » Sarcopenia is common in both the elderly and children with cerebral palsy. » Children with cerebral palsy have muscles that are much smaller than muscles in typically developing peers. » Injections of botulinum toxin type A (BoNT-A) result in acute muscle atrophy in animal models and in human subjects. » It is not known when or if muscles recover fully after injection of BoNT-A. » These findings have implications for management protocols.
    Type of Medium: Online Resource
    ISSN: 2329-9185
    URL: Article
    DOI: 10.2106/JBJS.RVW.18.00153
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
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  • 3
    Online Resource
    Online Resource
    A Systematic Review of Factors Associated with Health-Related Quality of Life in Adolescents and Adults with Cystic Fibrosis
    American Thoracic Society ; 2015
    In:  Annals of the American Thoracic Society Vol. 12, No. 3 ( 2015-03), p. 420-428
    Details
    In: Annals of the American Thoracic Society, American Thoracic Society, Vol. 12, No. 3 ( 2015-03), p. 420-428
    Type of Medium: Online Resource
    ISSN: 2329-6933 , 2325-6621
    URL: Article
    DOI: 10.1513/AnnalsATS.201408-393OC
    Language: English
    Publisher: American Thoracic Society
    Publication Date: 2015
    detail.hit.zdb_id: 2702474-X
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  • 4
    Online Resource
    Online Resource
    Effect of endoscopic sinus surgery on clinical outcomes in DeltaF508 cystic fibrosis patients
    Wiley ; 2021
    In:  Clinical Otolaryngology Vol. 46, No. 5 ( 2021-09), p. 941-947
    Details
    In: Clinical Otolaryngology, Wiley, Vol. 46, No. 5 ( 2021-09), p. 941-947
    Abstract: Chronic rhinosinusitis (CRS) is prevalent in the Cystic Fibrosis (CF) population. CRS exacerbations in CF are thought to contribute to pulmonary exacerbations. Literature regarding the impact of endoscopic sinus surgery (ESS) is inconclusive. This study examines rates of lung function decline and pulmonary exacerbation in CF patients who have undergone ESS. Design Retrospective review of medical records. Setting Academic Hospital. Participants 40 adult CF patients. Main outcome measures Rate of lung function decline (% predicted Forced Expiratory Volume in 1 second [ppFEV 1 ]), number of pulmonary exacerbations (IV/oral antibiotic therapy ± hospital admission) and total number days hospitalised 2‐year postoperatively was collected. CRS patients undergoing ESS were matched to those without ESS by gender, age, and F508del genotype. Results Forty patients (mean age 37.4, 60% male) were reviewed. No significant difference was found between the surgical group and controls in baseline ppFEV 1 (72.5% vs. 72.7%, P  = .98), 2‐year preoperative number of pulmonary exacerbations (3.05 vs. 1.65, P  = .10), or Lund‐Mackay scores (12.25 vs. 11.55, P  = .71). No significant difference was found in 1‐year (70.5% vs. 72.8%, P  = .84) or 2‐year (70.4% vs. 72.6% P  = .80) postoperative ppFEV 1 and 2‐year postoperative pulmonary exacerbations (1.7 vs. 1.45, P  = .87). A significant increase was identified in total number days hospitalised postoperatively (4.85, P  = .02). In the surgical group, no significant difference was identified between preoperative and postoperative ppFEV 1 , 1 year (−2.51%, P  = .32) and 2 years after ESS (−3.10%, P  = .51), postoperative rate of pulmonary exacerbations (−1.28, P  = .11), or in total number days hospitalised (3.74, P  = .14). Conclusions In this study, ESS does not appear to significantly improve ppFEV 1 or decrease the number of pulmonary exacerbations postoperatively.
    Type of Medium: Online Resource
    ISSN: 1749-4478 , 1749-4486
    URL: Issue
    URL: Article
    DOI: 10.1111/coa.v46.5
    DOI: 10.1111/coa.13751
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2206071-6
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  • 5
    Online Resource
    Online Resource
    Recent Levels of Evidence in Otolaryngology Journals
    SAGE Publications ; 2023
    In:  Annals of Otology, Rhinology & Laryngology Vol. 132, No. 5 ( 2023-05), p. 504-510
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 132, No. 5 ( 2023-05), p. 504-510
    Abstract: The development of evidence-based medicine has contributed to improved patient outcomes. This study aims to identify the trends in levels of evidence in otolaryngology journals over time, as represented by the 4 most widely circulated peer-reviewed otolaryngology journals. Methods: A review of all articles from 2007, 2010, 2013, 2016, and 2019, in 4 major otolaryngology journals. Data points included journal source, year of publication, country of origin, first author sex, and subspecialty category within otolaryngology. Level of evidence was determined based on the study’s primary research question and was graded on a scale of 1 (strongest) to 4 (weakest) based on the Oxford Centre of Evidence-based Medicine - Levels of Evidence guideline. Comparison of levels of evidence was performed using Kruskal-Wallis analysis of variance for ordinal data. Results: About 4297 articles were identified over 12 years. The number of research articles remained consistent over the 12 years of this study. Clinical research increased from 78.6% to 85.1%. Female first authorship increased from 20.3% in 2007 to 31.0% in 2019. Of 3558 articles that constituted clinical research from 2007 to 2019, level 1 studies increased from 0.9% to 3.6%, with level 4 studies remaining stable at an overall rate of 60.3%. Randomized controlled trials remained stable at 4.6% of all studies. Systematic reviews increased from 3.2% to 8.4%. Conclusion: This article provides an update on the levels of evidence to allow for an honest self-assessment of otolaryngology as a scientific field.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/00034894221104453
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2033055-8
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  • 6
    Online Resource
    Online Resource
    Environmental Triggers Associated With Empty Nose Syndrome Symptoms: A Cross-Sectional Study
    SAGE Publications ; 2019
    In:  Annals of Otology, Rhinology & Laryngology Vol. 128, No. 7 ( 2019-07), p. 601-607
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 128, No. 7 ( 2019-07), p. 601-607
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/0003489419833714
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2033055-8
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  • 7
    Online Resource
    Online Resource
    The One-Bone Forearm: A Review
    SAGE Publications ; 2022
    In:  HAND
    Details
    In: HAND, SAGE Publications
    Abstract: The one-bone forearm (OBF) is a salvage technique that may be used to correct global forearm instability secondary to osseous defects. This study aims to provide an overview of the contemporary literature regarding the OBF. A literature review was conducted electronically across MEDLINE, Embase, and PubMed databases in May 2020. Studies were eligible for inclusion if published in the English language; detailed the use of the OBF procedure to correct forearm instability; and were original data studies reporting qualitative or quantitative outcomes. Thirty-four studies, describing a cohort of 210 patients undergoing 211 OBFs, were documented in the literature. The primary etiology necessitating the OBF was trauma, followed by genetic/congenital disorders and infections. Technically, the OBF was most frequently achieved via an end-to-end osteosynthesis with plate fixation. In total, 85.0% (154/182) of OBF were fused in neutral rotation or varying degrees of pronation. Union was achieved in more than 80.0% (174/211) of OBFs. The OBF is a feasible salvage technique that has been used for a wide spectrum of pathology, providing satisfactory outcomes in most cases.
    Type of Medium: Online Resource
    ISSN: 1558-9447 , 1558-9455
    URL: Article
    DOI: 10.1177/15589447221084010
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2316440-2
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  • 8
    Online Resource
    Online Resource
    Authors’ Reply to K. Langdon and Colleagues’ Comment on: “Botulinum Toxin in the Management of Children with Cerebral Palsy”
    Springer Science and Business Media LLC ; 2019
    In:  Pediatric Drugs Vol. 21, No. 6 ( 2019-12), p. 497-499
    Details
    In: Pediatric Drugs, Springer Science and Business Media LLC, Vol. 21, No. 6 ( 2019-12), p. 497-499
    Type of Medium: Online Resource
    ISSN: 1174-5878 , 1179-2019
    URL: Article
    DOI: 10.1007/s40272-019-00359-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2043681-6
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Evaluation of sheep sinonasal endoscopic anatomy as a model for rhinologic research
    Wiley ; 2018
    In:  World Journal of Otorhinolaryngology - Head and Neck Surgery Vol. 4, No. 4 ( 2018-12), p. 268-272
    Details
    In: World Journal of Otorhinolaryngology - Head and Neck Surgery, Wiley, Vol. 4, No. 4 ( 2018-12), p. 268-272
    Abstract: Despite many publications describing sheep models for functional endoscopic sinus surgery (FESS) procedures, accurate endoscopic anatomical studies are lacking. There are no publications correlating computed tomography (CT) and 3D models with endoscopic anatomical descriptions. This study evaluates and describes the endoscopic anatomy of a sheep model. Methods Ten live sheep (20‐sides) were included. Two cadaveric specimens, imaged using thin slice CT for 3D reconstruction correlation were also included. Using endoscopy, anatomical structures were measured and described. Measurement of the same structures was carried out using the 3D imaging model. Results Three sets of turbinates were identified at 2.3, 5.1 and 8.5 cm from the anterior nasal sill. Frontal recess and uncinate process were identified at 12.7 cm. The septum has a bony and cartilaginous component and measures 10.5 cm. The sphenopalatine foramen was measured at 12.1 cm. All anatomical measurements were correlated with the measurements on the CT scan 3D volume‐rendering model, thereby allowing for an accurate description of the sheep sinonasal anatomy. Conclusion This study describes the endoscopic sinonasal anatomical measurements of the adult sheep. It is the first study to evaluate the sheep CT and endoscopic anatomy in order to determine its feasibility as an animal model for research in FESS.
    Type of Medium: Online Resource
    ISSN: 2095-8811 , 2589-1081
    URL: Article
    DOI: 10.1016/j.wjorl.2018.05.002
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2999715-X
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  • 10
    Online Resource
    Online Resource
    Triamcinolone versus Saline Soaked Spacers Post‐FESS
    Wiley ; 2012
    In:  Otolaryngology–Head and Neck Surgery Vol. 147, No. S2 ( 2012-08)
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 147, No. S2 ( 2012-08)
    Abstract: 1) To determine the effectiveness of triamcinolone‐soaked middle‐meatal‐spacers (MMS) within a perforated surgical gloved finger on improving healing and reducing inflammation in CRS patients post‐FESS. 2) To determine if triamcinolone‐soaked MMS within a perforated surgical gloved finger improves patient reported outcomes post‐FESS. Methods Double‐blind randomized controlled trial of 50 CRS patients undergoing FESS. Patients receive MMS in perforated glove fingers bilaterally, impregnated with triamcinolone (experimental arm) or saline (control). Primary outcome measure is the validated Philpott‐Javer endoscopic mucosal inflammation scoring system at postoperative days 14, 28, and 3, 6 months. SNOT‐22 scores were secondary outcomes. Results Our interim results, based on 36 participants, are optimistic. Patients in the triamcinolone group show clinically significant improvement in Philpott‐Javer endoscopic scores compared to saline controls at 28 days postoperative examination, however this difference was not currently statistically significant (1.185 vs 2.65; P =. 084). There was no significant difference between SNOT‐22 scores for the 2 groups at postoperative day 28 ( P =. 88). Conclusion Triamcinolone‐impregnated MMS may improve postoperative inflammation and healing in CRS patients following FESS.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1177/0194599812451438a262
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2008453-5
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