In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-01-12)
Abstract:
The SRY gene induces testis development even in XX individuals. However, XX/ Sry testes fail to produce mature sperm, due to the absence of Y chromosome carrying genes essential for spermatogenesis. XX/ Sry Sertoli cells show abnormalities in the production of lactate and cholesterol required for germ cell development. Leydig cells are essential for male functions through testosterone production. However, whether XX/ Sry adult Leydig cells (XX/ Sry ALCs) function normally remains unclear. In this study, the transcriptomes from XY and XX/ Sry ALCs demonstrated that immediate early and cholesterogenic gene expressions differed between these cells. Interestingly, cholesterogenic genes were upregulated in XX/ Sry ALCs, although downregulated in XX/ Sry Sertoli cells. Among the steroidogenic enzymes, CYP17A1 mediates steroid 17α-hydroxylation and 17,20-lyase reaction, necessary for testosterone production. In XX/ Sry ALCs, the latter reaction was selectively decreased. The defects in XX/ Sry ALCs, together with those in the germ and Sertoli cells, might explain the infertility of XX/ Sry testes.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-020-80741-z
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2615211-3
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