In:
Zeitschrift für Naturforschung B, Walter de Gruyter GmbH, Vol. 59, No. 1 ( 2004-1-1), p. 58-62
Abstract:
Two new erythroxylane diterpenes, named givotin A (1) and givotin B (2) were isolated from the bark of Givotia madagascariensis. Their structures have been established as 3α,12α-dihydroxy- 4(19),15-erythroxyladiene (1) and 3α-hydroxy-4(19),15-erythroxyladiene (2), respectively, on the basis of one and two-dimensional NMR spectroscopic studies ( 1 H, 13 C, COSY, HMQC, HMBC, NOESY, NOE difference spectra) as well as on mass spectral analysis. In addition six known compounds (3 - 8) have been isolated and identified. Cleistanthol (3), spruceanol (4) and 1,2- dihydroheudelotinol (5) demonstrated significant antitumor activities against three tumor cell lines (HM02, Hep G2, MCF7).
Type of Medium:
Online Resource
ISSN:
1865-7117
,
0932-0776
DOI:
10.1515/znb-2004-0109
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2004
detail.hit.zdb_id:
2078109-X
detail.hit.zdb_id:
124635-5
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