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  • 1
    Online Resource
    Online Resource
    An Approach to Studying Lung Cancer-related Proteins in Human Blood
    Elsevier BV ; 2005
    In:  Molecular & Cellular Proteomics Vol. 4, No. 10 ( 2005-10), p. 1480-1486
    Details
    In: Molecular & Cellular Proteomics, Elsevier BV, Vol. 4, No. 10 ( 2005-10), p. 1480-1486
    Type of Medium: Online Resource
    ISSN: 1535-9476
    URL: Article
    DOI: 10.1074/mcp.M500055-MCP200
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2005
    detail.hit.zdb_id: 2071375-7
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  • 2
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    Molecular epidemiology and antifungal susceptibilities of Cryptococcus species isolates from HIV and non-HIV patients in Southwest China
    Springer Science and Business Media LLC ; 2021
    In:  European Journal of Clinical Microbiology & Infectious Diseases Vol. 40, No. 2 ( 2021-02), p. 287-295
    Details
    In: European Journal of Clinical Microbiology & Infectious Diseases, Springer Science and Business Media LLC, Vol. 40, No. 2 ( 2021-02), p. 287-295
    Type of Medium: Online Resource
    ISSN: 0934-9723 , 1435-4373
    URL: Article
    DOI: 10.1007/s10096-020-04013-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1459049-9
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  • 3
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    Evaluation of a Cryptococcus capsular polysaccharide detection FungiXpert LFA (lateral flow assay) for the rapid diagnosis of Cryptococcosis
    Oxford University Press (OUP) ; 2022
    In:  Medical Mycology Vol. 60, No. 4 ( 2022-04-09)
    Details
    In: Medical Mycology, Oxford University Press (OUP), Vol. 60, No. 4 ( 2022-04-09)
    Abstract: Cryptococcus is an opportunistic pathogenic fungus and is the major cause of fungal meningitis. The cryptococcal antigen (CrAg) lateral flow assay (LFA) is an immunochromatographic test system that has simplified diagnosis as a point-of-care test. In this study, we evaluated the diagnostic performance of Cryptococcal capsular polysaccharide detection FungiXpert (Genobio Pharmaceutical, Tianjin, China) using serum and cerebrospinal fluid (CSF) samples for the diagnosis of cryptococcosis and investigated the cross-reaction of the assays to pathogenic fungi and bacterium by comparing it to the U.S. Food and Drug Administration (US FDA)-approved IMMY CrAg LFA. Eighty CSF and 119 serum/plasma samples from 158 patients were retrospectively collected to test for qualitative or semi-quantitative detection of CrAg. Cross-reaction of the assays was tested using 28 fungi and 1 bacterium. Compared to IMMY CrAg LFA, the FungiXpert LFA demonstrated 99.1% sensitivity and 98.9% specificity in the qualitative test. In the 96 semi-quantitative CrAg assay results, 39 (40.6%) test titers of FungiXpert LFA were 1–2 dilutions higher than those of IMMY CrAg LFA. The Intraclass Correlation Coefficient of the Semi-quantitative results of CrAg titer tests via the two assays was 0.976. Similar to IMMY CrAg LFA, FungiXpert LFA showed cross-reactivity with Trichosporon asahii. Compared with the IMMY CrAg LFA, the FungiXpert LFA showed an equal, yet, excellent performance. However, it is important to note that these two assays have potential cross-reactivity to T. asahii when diagnosing patients. FungiXpert LFA is a rapid screening method for the effective and practical diagnosis and treatment of cryptococcosis. Lay summary The FungiXpert LFA was developed to diagnose fungal meningitis caused by Cryptococcus yeasts, by using serum or cerebrospinal fluid. It was compared to an existing lateral flow assay (LFA). The FungiXpert LFA performed well in qualitative and semi-quantitative tests.
    Type of Medium: Online Resource
    ISSN: 1369-3786 , 1460-2709
    URL: Article
    DOI: 10.1093/mmy/myac020
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2020733-5
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  • 4
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    Safety and efficacy of anti-inflammatory therapy in patients with coronary artery disease: a systematic review and meta-analysis
    Springer Science and Business Media LLC ; 2022
    In:  BMC Cardiovascular Disorders Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Cardiovascular Disorders, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: The inflammation hypothesis of atherosclerosis has been put forward for more than 20 years. Although many animal experiments have suggested that anti-inflammatory therapy can inhibit the atherosclerotic process, the efficacy of anti-inflammatory therapy for patients with coronary artery disease (CAD) is still controversial. Therefore, this study aims to evaluate the safety and efficacy of anti-inflammatory drugs in patients with CAD. Method We conducted this systematic review and meta-analysis of randomized controlled trials by searching PubMed, EMBASE, web of science, and Cochrane Library database. The primary outcome was a composite outcome of cardiovascular death, myocardial infarction (MI), or stroke. The secondary outcomes included individual MI, coronary revascularization, cardiovascular death, all-cause death, and stroke. The relative risk (RR) and 95% confidence intervals (CI) for outcome events were calculated by the fixed effects model, and trial sequential analysis was applied to assess the results. Result A total of ten randomized controlled trials and 60,782 patients with CAD was included. Compared with patients receiving placebo, anti-inflammatory therapy significantly reduced the incidence of the primary outcome in patients with CAD (RR 0.93, 0.89–0.98, P  = 0.007). In addition, the anti-inflammatory therapy can also reduce the risk of MI (RR 0.90, 0.84–0.96, P  = 0.002) and coronary revascularization (RR 0.74, 0.66–0.84, P   〈  0.00001) remarkably. However, there was no significant difference in the incidence of cardiovascular death (RR 0.94, 0.86–1.02, P  = 0.14), all-cause death (RR 1.00, 0.94–1.07, P  = 0.98) and stroke (RR 0.96, 0.85–1.09, P  = 0.51) between two groups. Conclusions Anti-inflammatory therapy can reduce the incidence of the primary outcome in patients with CAD, especially the risk of MI and coronary revascularization. However, anti-inflammatory therapy increases the risk of infection. (Registered by PROSPERO, CRD 420212291032).
    Type of Medium: Online Resource
    ISSN: 1471-2261
    URL: Article
    DOI: 10.1186/s12872-022-02525-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2059859-2
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  • 5
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    Efficacy of intravascular imaging-guided drug-eluting stent implantation: a systematic review and meta-analysis of randomized clinical trials
    Springer Science and Business Media LLC ; 2022
    In:  BMC Cardiovascular Disorders Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Cardiovascular Disorders, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: Traditional angiography only displays two-dimensional images of the coronary arteries during stent implantation. However, intravascular imaging can show the structure of the vascular wall, plaque characteristics. This article aims to evaluate the efficacy of intravascular imaging-guided drug-eluting stent (DES) implantation. Method We conducted a systematic review and meta-analysis of randomized controlled trials of intravascular imaging-guided, including patients with DES implantation guided by intravascular ultrasound or optical coherence tomography and traditional angiography. The databases of PubMed, EMBASE, web of science, and Cochrane Library were searched. The primary outcome was target lesion revascularization (TLR). The secondary outcomes included the target vessel revascularization (TVR), myocardial infarction (MI), stent thrombosis (ST), cardiac death, all-cause death, and the major adverse cardiac events (MACE) during the 6–24 months follow-up. The fixed-effects model was used to calculate the relative risk (RR) and 95% confidence interval of the outcome event. Meanwhile, the trial sequence analysis was employed to evaluate the results. Result This meta-analysis included fourteen randomized controlled trials with 7307 patients. Compared with angiography-guided, intravascular imaging-guided DES implantation can significantly reduce the risk of TLR (RR 0.63, 0.49–0.82, P  = 0.0004), TVR (RR 0.66, 0.52–0.85, P  = 0.001), cardiac death (RR 0.58; 0.38–0.89; P  = 0.01), MACE (RR 0.67, 0.57–0.79; P   〈  0.00001) and ST (RR 0.43, 0.24–0.78; P  = 0.005). While there was no significant difference regarding MI (RR 0.77, 0.57–1.05, P  = 0.10) and all-cause death (RR 0.87, 0.58–1.30, P  = 0.50). Conclusions Compared with angiography, intravascular imaging-guided DES implantation is associated with better clinical outcomes in patients with coronary artery disease, especially complex lesions (Registered by PROSPERO, CRD 42021289205).
    Type of Medium: Online Resource
    ISSN: 1471-2261
    URL: Article
    DOI: 10.1186/s12872-022-02772-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2059859-2
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  • 6
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    Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress
    Wiley ; 2011
    In:  Phytotherapy Research Vol. 25, No. 4 ( 2011-04), p. 588-596
    Details
    In: Phytotherapy Research, Wiley, Vol. 25, No. 4 ( 2011-04), p. 588-596
    Abstract: The present study was carried out to investigate the lipid‐lowering effect of luteolin by using a cell model of steatosis induced by palmitate. Incubation of HepG2 cells with palmitate markedly increased lipid accumulation (Oil Red O staining), the genes involved in lipogenesis, including fatty acid synthase (FAS) and its upstream regulator sterol regulatory element binding protein 1c (SREBP‐1c), and reactive oxygen species (ROS) production. Luteolin enhanced the phosphorylation of AMP‐activated protein kinase α (AMPKα) and its primary downstream targeting enzyme, acetyl‐CoA carboxylase (ACC), up‐regulated gene expression of carnitine palmitoyl transferase 1 (CPT‐1), which is the rate‐limiting enzyme in mitochondrial fatty acid β‐oxidation, and down‐regulated SREBP‐1c and FAS mRNA levels in the absence and presence of palmitate. In addition, luteolin significantly decreased ROS production and ameliorated lipid accumulation in HepG2 cells caused by palmitate. Furthermore, intracellular triglyceride (TG) measurement indicated that the luteolin‐mediated reduction of enhanced TG caused by palmitate was blocked by pretreatment with the AMPK inhibitor, compound C. The results suggested that the lipid‐lowering effect of luteolin might be partially mediated by the up‐regulation of CPT‐1 and down‐regulation of SREBP‐1c and FAS gene expression, possibly by activation of the AMPK signaling pathway, and partially might be through its antioxidative actions. Copyright © 2010 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v25.4
    DOI: 10.1002/ptr.3305
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1493490-5
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  • 7
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    Oxepinamides: Novel Liver X Receptor Agonists from Aspergillus puniceus
    Wiley ; 2011
    In:  European Journal of Organic Chemistry Vol. 2011, No. 4 ( 2011-02), p. 802-807
    Details
    In: European Journal of Organic Chemistry, Wiley, Vol. 2011, No. 4 ( 2011-02), p. 802-807
    Abstract: Four novel oxepin‐containing pyrimidines, namely oxepinamides D–G ( 1 – 4 ), were isolated from cultures of Aspergillus puniceus F02Z‐1744. The structures of 1 – 4 were elucidated by analyzing their spectroscopic data generated by 1D and 2D NMR and MS methods. The configurations of 1 and 2 were established based on single‐crystal X‐ray crystallographic analysis. All four compounds 1 – 4 showed transcriptional activation on Liver X Receptor α (LXRα) with EC 50 values of 10.6, 12.8, 13.6, and 12.1 μ M , respectively.
    Type of Medium: Online Resource
    ISSN: 1434-193X , 1099-0690
    URL: Issue
    URL: Article
    DOI: 10.1002/ejoc.v2011.4
    DOI: 10.1002/ejoc.201000812
    RVK:
    VA 4073
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1475010-7
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  • 8
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    Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet
    Springer Science and Business Media LLC ; 2009
    In:  Acta Pharmacologica Sinica Vol. 30, No. 11 ( 2009-11), p. 1505-1512
    Details
    In: Acta Pharmacologica Sinica, Springer Science and Business Media LLC, Vol. 30, No. 11 ( 2009-11), p. 1505-1512
    Type of Medium: Online Resource
    ISSN: 1671-4083 , 1745-7254
    URL: Article
    DOI: 10.1038/aps.2009.150
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2009
    detail.hit.zdb_id: 2088565-9
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  • 9
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    Evaluate Short-Term Outcomes of abciximab in ST-Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Clinical Trials
    Hindawi Limited ; 2022
    In:  Journal of Interventional Cardiology Vol. 2022 ( 2022-5-29), p. 1-12
    Details
    In: Journal of Interventional Cardiology, Hindawi Limited, Vol. 2022 ( 2022-5-29), p. 1-12
    Abstract: Objectives. This meta-analysis was to verify the short-time efficacy and safety of abciximab in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Background. Abciximab has long-term efficacy in patients with STEMI undergoing PCI, but the short-term efficacy is still controversial. Methods. We conducted a systematic review and meta-analysis compared with or without abciximab in patients with STEMI undergoing PCI. The relevant randomized controlled trials were included by searching PubMed, EMBASE, Cochrane Library, and Web of Science databases and other sources. The relative risk (RR) and 95% confidence intervals (CI) of outcomes were calculated by the fixed-effects model. Results. Ten randomized controlled trials with 5008 patients met inclusion criteria. There were no significant differences in risk of all-cause death at 30-day (RR 0.79, CI 0.55–1.12, P = 0.18 ), major bleeding (1.37, 0.93–2.03, P = 0.11 ), and transfusion (1.23, 0.94–1.61, P = 0.13 ) between the two groups. However, there were significant differences in risk of all-cause death at 6 months (0.57, 0.36–0.90, P = 0.02 ), recurrent myocardial infarction (0.55, 0.33–0.92, P = 0.02 ), repeat revascularization (0.58, 0.43–0.78, P = 0.0004 ), final TIMI flow 〈 3 (0.77, 0.62–0.96, P = 0.02 ), minor bleeding (1.29, 1.02–1.63, P = 0.04 ), and thrombocytopenia (2.04, 1.40–2.97, P = 0.0002 ). Conclusions. The application of abciximab can lead to a lower risk of reinfarction, revascularization, and all-cause death at 6 months, but a higher risk of minor bleeding, and thrombocytopenia.
    Type of Medium: Online Resource
    ISSN: 1540-8183 , 0896-4327
    URL: Article
    DOI: 10.1155/2022/3911414
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2103585-4
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  • 10
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    Dual Antiplatelet Therapy After Drug-Eluting Stents Implantation in East Asians: A Network Meta-Analysis of Randomized Controlled Trials
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Journal of Cardiovascular Pharmacology Vol. 80, No. 2 ( 2022-08), p. 216-225
    Details
    In: Journal of Cardiovascular Pharmacology, Ovid Technologies (Wolters Kluwer Health), Vol. 80, No. 2 ( 2022-08), p. 216-225
    Abstract: Dual antiplatelet therapy (DAPT) is essential to prevent the risk of ischemia events, but it is difficult to avoid concurrent bleeding events. East Asians are associated with a higher tendency of bleeding than Caucasians, which may affect the DAPT duration. Therefore, this network meta-analysis to explore optimum DAPT duration for East Asians. The related randomized controlled trials that compared the different DAPT duration in East Asian patients were included by searching PubMed, EMBASE, and Cochrane Library database. The outcomes included myocardial infarction, stent thrombosis, all-cause death, stroke, and major bleeding. In addition, net adverse cardiac and cardiovascular events was defined as a composite outcome in this study. We calculated the odds ratio (OR) and 95% confidence intervals for end point events by the fixed effects model in the Bayesian’s network frame. We included a total of 12 randomized controlled trials with 30,640 patients. Compared with 12-month DAPT, 1- to 3-month DAPT is effective in myocardial infarction (OR 0.72, 0.46–1.08), stents thrombosis (OR 1.27, 0.59–2.84), all-cause death (OR 0.91, 0.65–1.28), and stroke (OR 0.89, 0.57–1.39). The 1- to 3-month DAPT was associated with a lower risk of major bleeding compared with 12-month DAPT (OR 0.55, 0.4–0.76), 6-month DAPT (OR 0.54, 0.31–0.94), and 〉 12-month DAPT (OR 0.43, 0.28–0.65). In addition, more than 12 months of DAPT did not reduce the incidence of myocardial infarction (OR 0.75, 0.51–1.11) and increased the risk of major bleeding (OR 1.28, 0.88–1.87) compared with 12-month DAPT. The 1- to 3-month DAPT was more secure and effective than the other 3 DAPT strategies. Although East Asians have a higher risk of bleeding, more than 12 months of DAPT does not increase this incidence of major bleeding.
    Type of Medium: Online Resource
    ISSN: 0160-2446
    URL: Article
    DOI: 10.1097/FJC.0000000000001288
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2049700-3
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