In:
Journal of Chemical Research, SAGE Publications, Vol. 41, No. 11 ( 2017-11), p. 664-667
Abstract:
Three novel 5-benzyl-1,3,4-thiadiazole derivatives were synthesised starting from phenylacetic acid derivatives. These compounds were characterised by NMR, HRMS and single-crystal X-ray diffraction analysis. 2-Pyrrolidyl-5-[2-(4-bromophenyl)methyl]-1,3,4-thiadiazole showed moderate acetylcholinesterase-inhibition activity with a 50% inhibitory concentration value of 33.16 μM. 2-Pyrrolidyl-5-[2-(4-bromophenyl)methyl] -1,3,4-thiadiazole and acetylcholinesterase docking was demonstrated using the Molecular Operating Environment program.
Type of Medium:
Online Resource
ISSN:
1747-5198
,
2047-6507
DOI:
10.3184/174751917X15094552081242
Language:
English
Publisher:
SAGE Publications
Publication Date:
2017
detail.hit.zdb_id:
3010810-X
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