In:
Synthesis, Georg Thieme Verlag KG, Vol. 55, No. 10 ( 2023-05), p. 1593-1601
Abstract:
An SbCl3-initiated Csp3
–Csp3 coupling between N-aryltetrahydroisoquinolines and nitromethanes was realized through the aerobic oxidation of sp
3 C–H bond, providing a series of nitromethylated tetrahydroisoquinoline derivatives in high yields. The results exhibited that SbCl3, as a cheap and commercially available reagent, is an efficient initiator to promote the direct functionalization of sp3 C–H bond with broad functional group tolerance, which is potentially applied to a wider range of C–H bond activation reactions.
Type of Medium:
Online Resource
ISSN:
0039-7881
,
1437-210X
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2023
detail.hit.zdb_id:
204080-3
detail.hit.zdb_id:
2033062-5
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