In:
Frontiers in Chemistry, Frontiers Media SA, Vol. 9 ( 2021-12-16)
Abstract:
Three new humulane-type sesquiterpenoids, penirolide A ( 1 ), penirolide B ( 2 ), and 10-acetyl-phomanoxide ( 3 ), together with three known compounds aurasperone A ( 4 ), pughiinin A ( 5 ), and cyclo( l -Leu- l -Phe) ( 6 ) were isolated from the endophytic fungus Penicillium sp . derived from the leaves of Carica papaya L. Their structures including their absolute configurations were determined based on the analysis of NMR and HRESIMS spectra, NMR chemical shifts, and ECD calculations. Compounds 2 , 3 , 5 , and 6 significantly inhibited glucagon-induced hepatic glucose production, with EC 50 values of 33.3, 36.1, 18.8, and 32.1 μM, respectively. Further study revealed that compounds 2 , 3 , 5 , and 6 inhibited hepatic glucose production by suppression of glucagon-induced cAMP accumulation.
Type of Medium:
Online Resource
ISSN:
2296-2646
DOI:
10.3389/fchem.2021.797858
DOI:
10.3389/fchem.2021.797858.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2711776-5
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