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  • Wiley  (21)
  • Ma, Jie  (21)
  • 2015-2019  (21)
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  • Wiley  (21)
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  • 2015-2019  (21)
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  • 1
    Online Resource
    Online Resource
    Super Bulk and Interfacial Toughness of Physically Crosslinked Double‐Network Hydrogels
    Wiley ; 2017
    In:  Advanced Functional Materials Vol. 27, No. 44 ( 2017-11)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 27, No. 44 ( 2017-11)
    Abstract: Conventional design wisdom prevents both bulk and interfacial toughness to be presented in the same hydrogel, because the bulk properties of hydrogels are usually different from the interfacial properties of the same hydrogels on solid surfaces. Here, a fully‐physically‐linked agar (the first network)/poly( N ‐hydroxyethyl acrylamide) (pHEAA, the second network), where both networks are physically crosslinked via hydrogen bonds, is designed and synthesized. Bulk agar/pHEAA hydrogels exhibit high mechanical properties (2.6 MPa tensile stress, 8.0 tensile strain, 8000 J m −2 tearing energy, 1.62 MJ m −3 energy dissipation), high self‐recovery without any external stimuli (62%/30% toughness/stiffness recovery), and self‐healing property. More impressively, without any surface modification, agar/pHEAA hydrogels can be easily and physically anchored onto different nonporous solid substrates of glass, titanium, aluminum, and ceramics to produce superadhesive hydrogel–solid interfaces (i.e., high interfacial toughness of 2000–7000 J m −2 ). Comparison of as‐prepared and swollen gels in water and hydrogen‐bond‐breaking solvents reveals that strong bulk toughness provides a structural basis for strong interfacial toughness, and both high toughness mainly stem from cooperative hydrogen bonds between and within two networks and between two networks and solid substrates. This work demonstrates a new gel system to achieve superhigh bulk and interfacial toughness on nonporous solid surfaces.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v27.44
    DOI: 10.1002/adfm.201703086
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Molecular Simulations of Amyloid Structures, Toxicity, and Inhibition
    Wiley ; 2017
    In:  Israel Journal of Chemistry Vol. 57, No. 7-8 ( 2017-07), p. 586-601
    Details
    In: Israel Journal of Chemistry, Wiley, Vol. 57, No. 7-8 ( 2017-07), p. 586-601
    Abstract: The misfolding and aggregation of proteins and peptides into amyloid fibrils are believed to be responsible for the dysfunction and death of neuron cells in many neurodegenerative diseases. Resolving the atomic structures of amyloid peptides at different aggregation stages by molecular simulations has opened new ways to probe the molecular mechanisms of amyloid aggregation, toxicity, and inhibition, as well as to validate computational data with available experimental ones. In this review article, we summarize some recent and important findings on: 1) a number of atomic structures of amyloid oligomers with typical β‐sheet‐rich conformations, related to amyloid aggregation; 2) different amyloid peptide‐induced membrane‐disruption mechanisms, related to amyloid toxicity; and 3) rational design of different amyloid inhibitors capable of preventing amyloid aggregation and toxicity, related to amyloid inhibition. All these findings will provide some mechanistic implications for molecular mechanisms of amyloid aggregation, toxicity, and inhibition, which are fundamentally and practically important for the treatment of amyloid diseases.
    Type of Medium: Online Resource
    ISSN: 0021-2148 , 1869-5868
    URL: Issue
    URL: Article
    DOI: 10.1002/ijch.v57.7-8
    DOI: 10.1002/ijch.201600075
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2066481-3
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  • 3
    Online Resource
    Online Resource
    Diagnostic value of strand‐specific mi RNA ‐101‐3p and mi RNA ‐101‐5p for hepatocellular carcinoma and a bioinformatic analysis of their possible mechanism of action
    Wiley ; 2018
    In:  FEBS Open Bio Vol. 8, No. 1 ( 2018-01), p. 64-84
    Details
    In: FEBS Open Bio, Wiley, Vol. 8, No. 1 ( 2018-01), p. 64-84
    Abstract: There is accumulating evidence that miRNA might serve as potential diagnostic and prognostic markers for various types of cancer. Hepatocellular carcinoma ( HCC ) is the most common type of malignant lesion but the significance of miRNAs in HCC remains largely unknown. The present study aimed to establish the diagnostic value of miR‐101‐3p/5p in HCC and then further investigate the prospective molecular mechanism via a bioinformatic analysis. First, the miR‐101 expression profiles and parallel clinical parameters from 362 HCC patients and 50 adjacent non‐ HCC tissue samples were downloaded from The Cancer Genome Atlas ( TCGA ). Second, we aggregated all miR‐101‐3p/5p expression profiles collected from published literature and the Gene Expression Omnibus and TCGA databases. Subsequently, target genes of miR‐101‐3p and miR‐101‐5p were predicted by using the mi RW alk database and then overlapped with the differentially expressed genes of HCC identified by natural language processing. Finally, bioinformatic analyses were conducted with the overlapping genes. The level of miR‐101 was significantly lower in HCC tissues compared with adjacent non‐ HCC tissues ( P 〈 0.001), and the area under the curve of the low miR‐101 level for HCC diagnosis was 0.925 ( P 〈 0.001). The pooled summary receiver operator characteristic ( SROC ) of miR‐101‐3p was 0.86, and the combined SROC curve of miR‐101‐5p was 0.80. Bioinformatic analysis showed that the target genes of both miR‐101‐3p and miR‐101‐5p are involved in several pathways that are associated with HCC . The hub genes for miR‐101‐3p and miR‐101‐5p were also found. Our results suggested that both miR‐101‐3p and miR‐101‐5p might be potential diagnostic markers in HCC , and that they exert their functions via targeting various prospective genes in the same pathways.
    Type of Medium: Online Resource
    ISSN: 2211-5463 , 2211-5463
    URL: Issue
    URL: Article
    DOI: 10.1002/feb4.2018.8.issue-1
    DOI: 10.1002/2211-5463.12349
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2651702-4
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  • 4
    Online Resource
    Online Resource
    Impact of oral hygiene on head and neck cancer risk in a Chinese population
    Wiley ; 2017
    In:  Head & Neck Vol. 39, No. 12 ( 2017-12), p. 2549-2557
    Details
    In: Head & Neck, Wiley, Vol. 39, No. 12 ( 2017-12), p. 2549-2557
    Abstract: Although the impact of oral hygiene on head and neck cancer risk has been investigated, few studies have been conducted among the Asian population. Methods We conducted a multicenter case‐control study to investigate this potential association. We performed unconditional multiple logistic regression models adjusted by potential confounders. Results We observed an inverse association of frequency of dental visits with head and neck cancer risk, with an adjusted odds ratio (OR) of 3.70 (95% CI 2.51‐5.45) for never dental visits compared with ≥1 time/year ( P trend 〈 .001). We also observed a positive association between the number of missing teeth and head and neck cancer risk, with an adjusted OR for ≥5 missing teeth compared with 〈 5 missing teeth of 1.49 (95% CI 1.08‐2.04). Combining multiple oral hygiene indicators, poor oral hygiene scores increased head and neck cancer risk. Conclusion Poor oral hygiene may increase head and neck cancer risk in the Chinese population. Therefore, improving oral hygiene may contribute to reducing the head and neck cancer risk in the Chinese population.
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v39.12
    DOI: 10.1002/hed.24929
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2001440-5
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  • 5
    Online Resource
    Online Resource
    Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population
    Wiley ; 2019
    In:  Head & Neck Vol. 41, No. 1 ( 2019-01), p. 92-102
    Details
    In: Head & Neck, Wiley, Vol. 41, No. 1 ( 2019-01), p. 92-102
    Abstract: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. Methods A multicenter case‐control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. Results Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. Conclusions Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. populations.
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v41.1
    DOI: 10.1002/hed.25383
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2001440-5
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  • 6
    Online Resource
    Online Resource
    Iron Oxide Supported Sulfhydryl-Functionalized Multiwalled Carbon Nanotubes for Removal of Arsenite from Aqueous Solution
    Wiley ; 2015
    In:  ChemPlusChem Vol. 80, No. 4 ( 2015-04), p. 740-748
    Details
    In: ChemPlusChem, Wiley, Vol. 80, No. 4 ( 2015-04), p. 740-748
    Type of Medium: Online Resource
    ISSN: 2192-6506
    URL: Article
    DOI: 10.1002/cplu.201402423
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2646595-4
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  • 7
    Online Resource
    Online Resource
    Retracted : Effects of cyclin D1 gene silencing on cell proliferation, cell cycle, and apoptosis of hepatocellular carcinoma cells
    Wiley ; 2018
    In:  Journal of Cellular Biochemistry Vol. 119, No. 2 ( 2018-02), p. 2368-2380
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 119, No. 2 ( 2018-02), p. 2368-2380
    Abstract: This study aims to investigate the effects of Cyclin D1 silencing on cell cycle, cell proliferation, and apoptosis of hepatocellular carcinoma cells (HCC). Cells were divided into the blank group, negative control group (HCC cells transfected with control shRNA), Cyclin D1 shRNA group (HCC cells transfected with Cyclin D1 shRNA), and the normal group (human normal liver L‐02 cells). Expressions of Cyclin D1, Caspase‐3, Bcl‐2, and C‐myc were detected by RT‐qPCR and Western blotting. Cell proliferation was detected by Cell Counting Kit‐8. Cell cycle and apoptosis were detected by flow cytometry. Tumor xenograft in nude mice was performed to detect in vivo tumorigenesis. HCC tissues and HCC cells exhibited elevated expression levels of Cyclin D1. Cyclin D1 expression levels was found to be correlated with tumor size and tumor staging. Compared with the normal group, the blank group showed enhanced cell proliferation, a reduction in the amount of cells in G0/G1 phase, increased number cells in S and G2/M phase, reduced apoptosis, elevated expressions of Cyclin D1, Bcl‐2, and C‐myc, decreased Caspase‐3 activity and significant tumorigenicity. In comparison with the blank group, the Cyclin D1 shRNA group revealed weakened cell proliferation, reduced cells in S and G2/M phase, increased cells in G0/G1 phase, increased Annexin V positive cell ratio, decreased expression of Cyclin D1, Bcl‐2, and C‐myc, elevated Caspase‐3 activity and inhibited tumorigenicity. In conclusion, Cyclin D1 gene silencing suppresses cell proliferation and inhibits cell apoptosis, which may be a new target approach in the treatment and management for HCC.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v119.2
    DOI: 10.1002/jcb.26400
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Validation of an LC‐MS/MS method for simultaneous determination of icotinib and its four major circulating metabolites in human plasma and its application in a pharmacokinetic study
    Wiley ; 2018
    In:  Biomedical Chromatography Vol. 32, No. 11 ( 2018-11)
    Details
    In: Biomedical Chromatography, Wiley, Vol. 32, No. 11 ( 2018-11)
    Abstract: In this study, a simple and sensitive LC‐MS/MS method was developed and validated for simultaneous determination of icotinib and its four circulating metabolites in human plasma. The analytes were extracted with acetonitrile and separated on a C 18 column using 2 m m ammonium acetate containing 0.2% formic acid and acetonitrile as mobile phase. The analytes were introduced into the mass spectrometer via an electrospray ionization source operated in positive ion mode. Precursor‐to‐product transitions were optimized to be m/z 392.2 → 304.1 for icotinib, m/z 424.1 → 278.2 for M1 and M2, m/z 408.2 → 320.1 for M3, m/z 410.2 → 322.1 for M4 and m/z 394.4 → 278.1 for IS. The assay showed good linearity over the concentration ranges of 0.1–600 ng/mL for icotinib and 0.1–200 ng/mL for metabolites, with correlation coefficients 〉 0.994 ( r   〉  0.994). The LLOQ was 0.1 ng/mL for each analyte. The intra‐ and inter‐day precisions (RSD) were ≤12.98% while the accuracy (RE) ranged from −8.76 to 12.01%. No significant matrix effect was observed. The validated method was successfully applied for the pharmacokinetic study of icotinib and its four circulating metabolites in human plasma after oral administration of icotinib at a single dose of 125 mg.
    Type of Medium: Online Resource
    ISSN: 0269-3879 , 1099-0801
    URL: Issue
    URL: Article
    DOI: 10.1002/bmc.v32.11
    DOI: 10.1002/bmc.4327
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479945-5
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    The effects of extruded corn flour on rheological properties of wheat‐based composite dough and the bread quality
    Wiley ; 2019
    In:  Food Science & Nutrition Vol. 7, No. 9 ( 2019-09), p. 2977-2985
    Details
    In: Food Science & Nutrition, Wiley, Vol. 7, No. 9 ( 2019-09), p. 2977-2985
    Abstract: The effects of extruded corn flour (ECF) on the rheological properties of the wheat‐based composite dough and quality of the bread were investigated. The RVA results of the composite flour with ECF showed weak thermal viscosity and resistance to starch retrogradation. Mixolab tests revealed that the water absorption capacity increased with the increasing amount of ECF, while dough development time (DT) and dough stability (ST) showed a downward trend, and the composite dough became more resistant to retrogradation. The microstructure of the composite dough showed that the presence of both ECF and unextruded corn flour (UECF) resulted in a more broken gluten matrix. The breads made from the composite flour with ECF had significantly softer texture, lower hardening percentage with storage time, darker crust color, larger specific volume, and higher sensory scores than the UECF ones. It is concluded that the extrusion of corn flour is an effective way to improve the quality of the composite bread and retard staling during storage.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    URL: Article
    DOI: 10.1002/fsn3.v7.9
    DOI: 10.1002/fsn3.1153
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2703010-6
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  • 10
    Online Resource
    Online Resource
    Using Multifunctional Polymeric Soft Template for Synthesizing Nitrogen and Phosphorus Co–Doped Mesoporous Carbon Frameworks Electrocatalysts for Oxygen Reduction Reaction
    Wiley ; 2018
    In:  ChemistrySelect Vol. 3, No. 31 ( 2018-08-23), p. 9013-9020
    Details
    In: ChemistrySelect, Wiley, Vol. 3, No. 31 ( 2018-08-23), p. 9013-9020
    Abstract: To replace high‐cost and non‐resistant platinum‐based electrocatalysts for oxygen reduction reaction (ORR), the development of low‐cost, durable and high‐efficiency nonprecious metal catalysts is urgently needed. Thereinto, metal‐free heteroatom‐doped carbon materials as one of the promising candidates are quite satisfying for its designability of material properties, remarkable electrocatalytic activity and unexceptionable durability. In this work, a novel and rational method by using multifunctional polymeric soft template: poly [cyclotriphosphazene‐co‐(4, 4’‐(hexafluoroisopropylidene) diphenol)] (PZAF) particles for synthesis PZAF@PANI composite which is further treated under high temperature for generating N, P co‐doped mesoporous carbons (NPMPCs) is utilized. The resultant NPMPCs exhibit a mesoporous structure with ultra large specific surface area (1465.091 m 2 g −1 ) and total pore volume (1.068 cm 3 g −1 ), which can optimize the ORR active sites derived from the N, P co‐doping. Based on these structural features, NPMPCs possess outstanding ORR activity, admirable durability and brilliant methanol tolerance, comparable or even better than that of commercial 20% Pt/C. The correlationship between the particular porous structure derived from the decomposition of PZAF particles and the nitrogen and phosphorus species in the carbon frameworks of the electrocatalysts with considerable catalytic activity are thoroughly investigated.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v3.31
    DOI: 10.1002/slct.201801177
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2844262-3
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