In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2015, No. 29 ( 2015-10), p. 4935-4945
Kurzfassung:
Seven novel 5‐substituted phenylthiazole oxadiazolethiones: [Me‐PTOT(H)], [MeO‐PTOT(H)] , [MeS‐PTOT(H)], [F‐PTOT(H)] , [Cl‐PTOT(H)], [Br‐PTOT(H)] , and [CF 3 ‐PTOT(H)], {where X‐PTOT(H) = 5‐[2‐(4‐X)thiazol‐4‐yl] ‐1,3,4‐oxadiazole‐2(3 H )‐thione, 4‐X = C 6 H 4 }, were synthesised from their corresponding thioamides. From these seven heteroleptic thiolatobismuth complexes: BiPh(Me‐PTOT) 2 6 , BiPh(MeO‐PTOT) 2 7 , BiPh(MeS‐PTOT) 2 8 , BiPh(F‐PTOT) 2 9 , BiPh(Cl‐PTOT) 2 10 , BiPh(Br‐PTOT) 2 11 and BiPh(CF 3 ‐PTOT) 2 12 were synthesised and characterised. Complexes [ 10 (DMSO) 2 ] and [ 11 (DMSO) 2 ] were structurally characterised using X‐ray diffraction. Evaluation of the antibacterial properties of the thiones and their Bi III complexes against Mycobacterium smegmatis, Staphylococcus aureus ( S. aureus ), Methicillin‐resistant Staphylococcus aureus (MRSA), Vancomycin‐resistant Enterococcus (VRE), Enterococcus faecalis (E. faecalis) and Escherichia coli ( E. coli ) showed that all bismuth(III) complexes were highly effective against all the bacteria, as demonstrated by very low MIC values (1.1–2.1 μ M ). Complexes BiPh(Me‐PTOT) 2 6 , BiPh(Cl‐PTOT) 2 10 and BiPh(Br‐PTOT) 2 11 , showed best activity against the multi‐drug resistant bacteria VRE and MRSA with an MIC value of 1.0 μ M . All these complexes and their corresponding thiones failed to show any prominent activity against M. smegmatis and E. coli , even at high concentrations. These complexes showed little or no toxicity towards mammalian COS‐7 cells at 20 μg/mL.
Materialart:
Online-Ressource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2015.29
DOI:
10.1002/ejic.201500795
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
1475009-0
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