In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-12-12)
Kurzfassung:
The research on secondary metabolites of Aspergillus lentulus afforded eight unusual heterodimeric tetrahydroxanthone derivatives, lentulins A−H ( 2 − 9 ), along with the known compound neosartorin ( 1 ). Compounds 1 − 6 exhibited potent antimicrobial activities especially against methicillin-resistant Staphylococci . Their absolute configurations, particularly the axial chiralities, were unambiguously demonstrated by a combination of electronic circular dichroism (ECD), Rh 2 (OCOCF 3 ) 4 -induced ECD experiments, modified Mosher methods, and chemical conversions. Interestingly, compounds 1 – 4 were the first samples of atropisomers within the dimeric tetrahydroxanthone class. Further investigation of the relationships between their axial chiralities and ECD Cotton effects led to the proposal of a specific CD Exciton Chirality rule to determine the axial chiralities in dimeric tetrahydroxanthones and their derivatives.
Materialart:
Online-Ressource
ISSN:
2045-2322
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2016
ZDB Id:
2615211-3
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