In:
The Plant Journal, Wiley, Vol. 109, No. 3 ( 2022-02), p. 555-567
Abstract:
Twenty‐one 2,3‐oxidosqualene cyclases (OSCs) from four celastrol‐producing plants of Celastraceae were isolated and nine of them were identified as friedelane‐type triterpene cyclases, which could catalyze the conversion of 2,3‐oxidosqualene into friedelin, β ‐amyrin, and α ‐amyrin. Among them, friedelin is an important precursor for the biosynthesis of celastrol. Through molecular evolution analysis, molecular docking, and site‐directed mutagenesis, our study provides some references for further research on the mechanisms underlying friedelin biosynthesis.
Type of Medium:
Online Resource
ISSN:
0960-7412
,
1365-313X
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2020961-7
SSG:
12
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