GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (2)
  • Lu, Yi  (2)
Material
Publisher
  • Wiley  (2)
Person/Organisation
Language
Years
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs
    Wiley ; 2022
    In:  Journal of Child Psychology and Psychiatry Vol. 63, No. 12 ( 2022-12), p. 1513-1522
    Details
    In: Journal of Child Psychology and Psychiatry, Wiley, Vol. 63, No. 12 ( 2022-12), p. 1513-1522
    Abstract: Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS‐psychiatric symptom associations were attributable to indirect versus direct pathways. Methods The sample consisted of 3,907 dizygotic (DZ) twin pairs. In childhood, their parents rated them on 98 symptoms. In adolescence ( n  = 2,393 DZ pairs), both the parents and the twins rated themselves on 20 symptoms. We extracted one general and seven specific factors from the childhood data, and one general and three specific factors from the adolescent data. We then regressed each general factor model onto ten psychiatric PRS simultaneously. We first conducted the regressions between individuals (β) and then within DZ twin pairs (β w ), which controls for indirect pathways. Results In childhood, the PRS for ADHD predicted general psychopathology (β = 0.09, 95% CI: [0.06, 0.12]; β w  = 0.07 [0.01, 0.12]). Furthermore, the PRS for ADHD predicted specific inattention (β = 0.04 [0.00, 0.08] ; β w  = 0.09 [0.01, 0.17]) and specific hyperactivity (β = 0.07 [0.04, 0.11] ; β w  = 0.09 [0.01, 0.16]); the PRS for schizophrenia predicted specific learning (β = 0.08 [0.03, 0.13] ; β w  = 0.19 [0.08, 0.30]) and specific inattention problems (β = 0.05 [0.01, 0.09] ; β w  = 0.10 [0.02, 0.19]); and the PRS for neuroticism predicted specific anxiety (β = 0.06 [0.02, 0.10] ; β w  = 0.06 [0.00, 0.12]). Overall, the PRS‐general factor associations were similar between individuals and within twin pairs, whereas the PRS‐specific factors associations amplified by 84% within pairs. Conclusions This implies that PRS‐psychiatric symptom associations did not appear attributable to indirect pathways such as population stratification, assortative mating, or mediation via parental environments. Rather, genetics appeared to directly influence symptomatology.
    Type of Medium: Online Resource
    ISSN: 0021-9630 , 1469-7610
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpp.v63.12
    DOI: 10.1111/jcpp.13605
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1470297-6
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Sex‐specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population
    Wiley ; 2018
    In:  Journal of Child Psychology and Psychiatry Vol. 59, No. 8 ( 2018-08), p. 908-916
    Details
    In: Journal of Child Psychology and Psychiatry, Wiley, Vol. 59, No. 8 ( 2018-08), p. 908-916
    Abstract: Attention deficit hyperactivity disorder ( ADHD ) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that females might be protected from developing ADHD , requiring a higher burden of genetic risk to manifest the disorder. Methods We tested these two hypotheses, using common variant genetic data from two population‐based cohorts. First, we tested whether females and males diagnosed with anxiety or depression differ in terms of their genetic risk for ADHD , assessed as polygenic risk scores ( PRS ). Second, we tested whether females and males with ADHD differed in ADHD genetic risk burden. We used three different diagnostic definitions: registry‐based clinical diagnoses, screening‐based research diagnoses and algorithm‐based research diagnoses, to investigate possible referral biases. Results In individuals with a registry‐based clinical diagnosis of anxiety or depression, females had higher ADHD PRS than males [ OR ( CI ) = 1.39 (1.12–1.73)] but there was no sex difference for screening‐based [ OR ( CI ) = 1.15 (0.94–1.42)] or algorithm‐based [ OR ( CI ) = 1.04 (0.89–1.21)] diagnoses. There was also no sex difference in ADHD PRS in individuals with ADHD diagnoses that were registry‐based [ OR ( CI ) = 1.04 (0.84–1.30)], screening‐based [ OR ( CI ) = 0.96 (0.85–1.08)] or algorithm‐based [ OR ( CI ) = 1.15 (0.78–1.68)]. Conclusions This study provides genetic evidence that ADHD risk may be more likely to manifest or be diagnosed as anxiety or depression in females than in males. Contrary to some earlier studies, the results do not support increased ADHD genetic risk in females with ADHD as compared to affected males.
    Type of Medium: Online Resource
    ISSN: 0021-9630 , 1469-7610
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpp.2018.59.issue-8
    DOI: 10.1111/jcpp.12874
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1470297-6
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...