In:
Angewandte Chemie, Wiley, Vol. 134, No. 7 ( 2022-02-07)
Abstract:
Here, we report a copper‐catalyzed asymmetric cascade cyclization/[1,2]‐Stevens‐type rearrangement via a non‐diazo approach, leading to the practical and atom‐economic assembly of various valuable chiral chromeno[3,4‐ c ]pyrroles bearing a quaternary carbon stereocenter in generally moderate to good yields with wide substrate scope and exc ellent enantioselectivities (up to 99 % ee). Importantly, this protocol not only represents the first example of catalytic asymmetric [1,2]‐Stevens‐type rearrangement based on alkynes but also constitutes the first asymmetric formal carbene insertion into the Si−O bond .
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.202115554
Language:
English
Publisher:
Wiley
Publication Date:
2022
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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