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  • 1
    Online Resource
    Online Resource
    Comparing the Nucleocapsid Proteins of Human Coronaviruses: Structure, Immunoregulation, Vaccine, and Targeted Drug
    Frontiers Media SA ; 2022
    In:  Frontiers in Molecular Biosciences Vol. 9 ( 2022-4-29)
    Details
    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 9 ( 2022-4-29)
    Abstract: The seven pathogenic human coronaviruses (HCoVs) include HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, which usually cause mild upper respiratory tract diseases, and SARS-CoV, MERS-CoV, and SARS-CoV-2, which cause a severe acute respiratory syndrome. The nucleocapsid (N) protein, as the dominant structural protein from coronaviruses that bind to the genomic RNA, participates in various vital activities after virus invasion and will probably become a promising target of antiviral drug design. Therefore, a comprehensive literature review of human coronavirus’ pathogenic mechanism and therapeutic strategies is necessary for the control of the pandemic. Here, we give a systematic summary of the structures, immunoregulation, and potential vaccines and targeted drugs of the HCoVs N protein. First, we provide a general introduction to the fundamental structures and molecular function of N protein. Next, we outline the N protein mediated immune regulation and pathogenesis mechanism. Finally, we comprehensively summarize the development of potential N protein-targeted drugs and candidate vaccines to treat coronavirus disease 2019 (COVID-19). We believe this review provides insight into the virulence and transmission of SARS-CoV-2 as well as support for further study on epidemic control of COVID-19.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    URL: Article
    DOI: 10.3389/fmolb.2022.761173
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2814330-9
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  • 2
    Online Resource
    Online Resource
    Neutrophil extracellular traps degrade fibronectin in a rat model of bronchopulmonary dysplasia induced by perinatal exposure to lipopolysaccharide
    Wiley ; 2020
    In:  Journal of Cellular and Molecular Medicine Vol. 24, No. 24 ( 2020-12), p. 14645-14649
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 24, No. 24 ( 2020-12), p. 14645-14649
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v24.24
    DOI: 10.1111/jcmm.15842
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2076114-4
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  • 3
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    Online Resource
    IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia
    Springer Science and Business Media LLC ; 2020
    In:  Cell Death Discovery Vol. 6, No. 1 ( 2020-05-04)
    Details
    In: Cell Death Discovery, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2020-05-04)
    Abstract: Bronchopulmonary dysplasia (BPD) is the leading cause of chronic lung disease in preterm neonates. Extracellular matrix (ECM) abnormalities reshape lung development, contributing to BPD progression. In the present study, we first discovered that the ECM component fibronectin was reduced in the pulmonary tissues of model mice with BPD induced by lipopolysaccharide (LPS) and hyper-oxygen. Meanwhile, interleukin-33 (IL-33) and other inflammatory cytokines were elevated in BPD lung tissues. LPS stimulated the production of IL-33 in alveolar epithelial cells via myeloid differentiation factor 88 (MyD88), protein 38 (p38), and nuclear factor-kappa B (NF-κB) protein 65 (p65). Following the knockout of either IL-33 or its receptor suppression of tumorigenicity 2 (ST2) in mice, BPD disease severity was improved, accompanied by elevated fibronectin. ST2 neutralization antibody also relieved BPD progression and restored the expression of fibronectin. IL-33 induced the formation of neutrophil extracellular traps (NETs), which degraded fibronectin in alveolar epithelial cells. Moreover, DNase-mediated degradation of NETs was protective against BPD. Finally, a fibronectin inhibitor directly decreased fibronectin and caused BPD-like disease in the mouse model. Our findings may shed light on the roles of IL-33-induced NETs and reduced fibronectin in the pathogenesis of BPD.
    Type of Medium: Online Resource
    ISSN: 2058-7716
    URL: Article
    DOI: 10.1038/s41420-020-0267-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2842546-7
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  • 4
    Online Resource
    Online Resource
    Data_Sheet_1.zip
    Frontiers Media SA ; 2022
    In:  Frontiers in Microbiology Vol. 13 ( 2022-7-22)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 13 ( 2022-7-22)
    Abstract: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world and has had a devastating impact on health and economy. The biochemical characterization of SARS-CoV-2 proteins is important for drug design and development. In this study, we discovered that the SARS-CoV-2 nucleocapsid protein can melt double-stranded DNA (dsDNA) in the 5′-3′ direction, similar to SARS-CoV-2 nonstructural protein 13. However, the unwinding activity of SARS-CoV-2 nucleocapsid protein was found to be more than 22 times weaker than that of SARS-CoV-2 nonstructural protein 13, and the melting process was independent of nucleoside triphosphates and Mg 2+ . Interestingly, at low concentrations, the SARS-CoV-2 nucleocapsid protein exhibited a stronger annealing activity than SARS-CoV-2 nonstructural protein 13; however, at high concentrations, it promoted the melting of dsDNA. These findings have deepened our understanding of the SARS-CoV-2 nucleocapsid protein and will help provide novel insights into antiviral drug development.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2022.851202
    DOI: 10.3389/fmicb.2022.851202.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587354-4
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  • 5
    Online Resource
    Online Resource
    Research on Unexpected DNS Response from Open DNS Resolvers
    Oxford University Press (OUP) ; 2022
    In:  The Computer Journal Vol. 65, No. 9 ( 2022-09-16), p. 2276-2298
    Details
    In: The Computer Journal, Oxford University Press (OUP), Vol. 65, No. 9 ( 2022-09-16), p. 2276-2298
    Abstract: As the backbone of the domain name system (DNS), DNS resolvers are essential to the Internet. Nowadays, the measurement of DNS resolvers, especially open DNS resolvers, has become a research focus. Previous research works show that DNS responses returned from some open DNS resolvers are not expected for clients and the Internet. We call these DNS responses ‘unexpected DNS responses’. Research on unexpected DNS responses is beneficial to the research, usage and management of open DNS resolvers. This paper explores unexpected DNS responses returned from open DNS resolvers in terms of identification and classification to better understand the behaviours of open DNS resolvers. First, an identification method is proposed to identify all kinds of DNS responses from each section of DNS messages. Second, a classification method is proposed to classify unexpected DNS responses by their influences on clients and the Internet. Furthermore, an efficient identification and classification method is proposed to simplify the above process. Among about 9 million responding open DNS resolvers in the experiments on the IPv4 address space, about 40% return unexpected DNS responses. Experimental results show that the proposed methods can identify and classify all kinds of DNS responses returned from open DNS resolvers.
    Type of Medium: Online Resource
    ISSN: 0010-4620 , 1460-2067
    URL: Article
    DOI: 10.1093/comjnl/bxab063
    RVK:
    SQ 1100
    RVK:
    SA 3740
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1477172-X
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  • 6
    Online Resource
    Online Resource
    Next‐generation sequencing to investigate circular RNA profiles in the peripheral blood of preterm neonates with bronchopulmonary dysplasia
    Wiley ; 2020
    In:  Journal of Clinical Laboratory Analysis Vol. 34, No. 7 ( 2020-07)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 7 ( 2020-07)
    Abstract: Circular RNAs (circRNAs) are emerging noncoding RNAs that are involved in many biological processes and diseases. The expression profile of circRNAs in preterm neonates with bronchopulmonary dysplasia (BPD) remains unresolved. Methods In BPD infants, peripheral venous blood was drawn and circRNAs were extracted and sequenced by next‐generation sequencing. The levels of the selected circRNAs were measured by real‐time quantitative reverse transcription PCR. Results Among thousands of circRNAs, 491 circRNAs were significantly changed. Among the top 10 changed circRNAs, hsa_circ_0003122, hsa_circ_0003357, hsa_circ_0009983, hsa_circ_0003037, and hsa_circ_0009256 were significantly increased, while hsa_circ_0014932, hsa_circ_0015109, hsa_circ_0017811, hsa_circ_0020588, and hsa_circ_0015066 were significantly decreased. These altered circRNAs are involved in complicated biological functions and signaling pathways. Additionally, hsa_circ_0005577 (hsa_circ_FANCL), which was significantly increased in the moderate‐to‐severe BPD subjects, was correlated with oxygenation therapy. Conclusion These results suggest that an aberrant circRNA profile in the peripheral blood of BPD infants might be important in BPD pathogenesis.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v34.7
    DOI: 10.1002/jcla.23260
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001635-9
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