Online Resource
Bentham Science Publishers Ltd.
;
2022
In:
Current Drug Metabolism Vol. 23, No. 1 ( 2022-01), p. 2-7
In:
Current Drug Metabolism, Bentham Science Publishers Ltd., Vol. 23, No. 1 ( 2022-01), p. 2-7
Abstract:
Dosing time-dependency of pharmacokinetics (or chronopharmacokinetics) has been long recognized.
Studies in recent years have revealed that daily rhythmicity in expression of drug-metabolizing enzymes and transporters (DMETs) are key factors determining chronopharmacokinetics. In this article, we briefly summarize current
knowledge with respect to circadian mechanisms of DMETs and discuss how rhythmic DMETs are translated to drug chronoeffects. More importantly, we present our perspectives on pharmacokinetics-based chronotherapy.
Type of Medium:
Online Resource
ISSN:
1389-2002
DOI:
10.2174/1389200223666220106124218
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
SSG:
15,3
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