In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 71, No. 8_Supplement ( 2011-04-15), p. 3741-3741
Abstract:
Background: Breast tumors from African American women (AAW) have less favorable pathological characteristics and higher mortality rates than Caucasian women. While socioeconomic status may influence prognosis, biological factors are also likely to contribute to tumor behavior. Methods: Patients treated within an equal-access military medical center were matched by age, grade and ER status. Tumors were subjected to laser microdissection and RNA hybridized to HG U133A 2.0 microarrays. Data was analyzed using Partek Genomics Suite using a cutoff of P & lt;0.001, 1.5-fold change. Microarray results were validated by qRT-PCR. Results: Twenty-six pairs of matched tumor samples were identified. Clinico-pathological factors did not differ significantly for age at diagnosis, tumor size or stage, lymph node, hormone receptor, or HER2 status. Mortality was similar between the two groups. One putative and nineteen known genes were differentially expressed between populations with five genes expressed at higher and 15 genes at lower levels in tumors from AAW; hierarchical clustering classified 23/26 AAW and 26/26 CW correctly. Differential expression was validated (P & lt;0.001) for PSPHL (higher in AAW) and LTF and PSD3 (lower in AAW). Conclusions: Despite matching of tumors by pathological characteristics and provision of medical care in an equal-access health care system, a molecular signature differentiating AAW from CW tumors was detected, supporting a model in which aggressive tumor phenotypes are driven by molecular differences within the tumors. These differentially expressed genes are involved in immune response, cell cycle and metastasis and thus may contribute to the poor outcome in AAW. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3741. doi:10.1158/1538-7445.AM2011-3741
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2011-3741
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2011
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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