In:
Journal of Craniofacial Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 30, No. 5 ( 2019-07), p. e474-e477
Kurzfassung:
Skin soft tissue dilatation has emerged as one of the most prominent methods to skin defects spanning large areas. However, effective expansion of additional skin tissue is still the most challenging problem. This study aimed to understand the potential role of circular RNAs (circRNAs) in gene regulation during skin regeneration via analysis of the circRNA expression profile of skin tissue during skin regeneration under mechanical tension. In total, 1039 circRNAs were identified, of which 126 were newly identified. Furthermore, 48 circRNAs were differentially expressed between the experimental and control groups, which were annotated with gene ontology and kyoto encyclopedia of genes and genomes functions, and the regulatory network of microRNA (miRNA)–circRNA was established. The present results provide a theoretical basis for future studies on the mechanism underlying skin regeneration.
Materialart:
Online-Ressource
ISSN:
1049-2275
,
1536-3732
DOI:
10.1097/SCS.0000000000005592
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2019
ZDB Id:
2060546-8
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