In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-08-11)
Abstract:
Rhodoterpenoids A‒C ( 1 ‒ 3 ), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D ( 4 ), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography−mass spectrometry−solid-phase extraction−nuclear magnetic resonance (HPLC‒MS‒SPE‒NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacyclic carbon backbone. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Plausible biogenetic pathways for 1 ‒ 4 were proposed. Compounds 1 and 4 showed potential activity against herpes simplex virus 1 (HSV-1) with IC 50 values of 8.62 and 6.87 μ M, respectively.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-017-06320-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2017
detail.hit.zdb_id:
2615211-3
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