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  • 1
    Online Resource
    Online Resource
    Frontiers Media SA ; 2024
    In:  Frontiers in Cellular and Infection Microbiology Vol. 14 ( 2024-2-23)
    In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 14 ( 2024-2-23)
    Abstract: Klebsiella pneumoniae is a Gram-negative bacterium within the Enterobacteriaceae family that can cause multiple systemic infections, such as respiratory, blood, liver abscesses and urinary systems. Antibiotic resistance is a global health threat and K. pneumoniae warrants special attention due to its resistance to most modern day antibiotics. Biofilm formation is a critical obstruction that enhances the antibiotic resistance of K. pneumoniae . However, knowledge on the molecular mechanisms of biofilm formation and its relation with antibiotic resistance in K. pneumoniae is limited. Understanding the molecular mechanisms of biofilm formation and its correlation with antibiotic resistance is crucial for providing insight for the design of new drugs to control and treat biofilm-related infections. In this review, we summarize recent advances in genes contributing to the biofilm formation of K. pneumoniae , new progress on the relationship between biofilm formation and antibiotic resistance, and new therapeutic strategies targeting biofilms. Finally, we discuss future research directions that target biofilm formation and antibiotic resistance of this priority pathogen.
    Type of Medium: Online Resource
    ISSN: 2235-2988
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2619676-1
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Journal of International Medical Research Vol. 51, No. 1 ( 2023-01), p. 030006052211474-
    In: Journal of International Medical Research, SAGE Publications, Vol. 51, No. 1 ( 2023-01), p. 030006052211474-
    Abstract: To identify key genes involved in occurrence and development of polycystic ovary syndrome (PCOS). Methods By downloading the GSE85932 dataset from the GEO database, we used bioinformatical analysis to analyse differentially expressed genes (DEGs) from blood samples of eight women with PCOS and eight matched controls. Following bioinformatic analysis, we performed a cross-sectional study of serum samples taken from 79 women with PCOS and 36 healthy controls. Results From the 178 DEGs identified by bioinformatical analysis, 15 genes were identified as significant, and of these, ORM1 and ORM2 were selected for further verification as potential biomarkers for PCOS. Serum ORM1 and ORM2 levels were significantly increased in women with PCOS, and had a high diagnostic value. ORM1 and ORM2 were positively correlated with testosterone, cholesterol, and triglycerides. ORM1 levels were negatively correlated with high density lipoprotein (HDL) while ORM2 levels showed no significant correlation. Conclusions ORM may be an effective biomarker for the diagnosis of PCOS and its monitoring may be a useful therapeutic strategy.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2082422-1
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  • 3
    Online Resource
    Online Resource
    IOP Publishing ; 2023
    In:  Journal of Physics: Conference Series Vol. 2427, No. 1 ( 2023-02-01), p. 012042-
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2427, No. 1 ( 2023-02-01), p. 012042-
    Abstract: With the rapid development of new energy power generation technology and the promotion and application of energy storage in smart grids, energy storage is more and more favored by people. Firstly, the energy storage technology is classified, and its role in the power grid is analyzed. Then, the economy of centralized and distributed energy storage is analyzed. Further, according to the technical and economic characteristics of centralized energy storage and distributed energy storage, the applications of these two types of energy storage are introduced. Finally, based on the characteristics of renewable energy in Jilin Province, recommendations are made for the placement of energy storage in Jilin Province in the context of “carbon neutrality and carbon peaking.”
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2166409-2
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  • 4
    In: European Journal of Medical Genetics, Elsevier BV, Vol. 65, No. 9 ( 2022-09), p. 104554-
    Type of Medium: Online Resource
    ISSN: 1769-7212
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2186601-6
    SSG: 12
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  • 5
    In: BMC Plant Biology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Cotton ( Gossypium hirsutum L.) is one of the most important cash crops worldwide. Fine roots are the central part of the root system that contributes to plant water and nutrient uptake. However, the mechanisms underlying the response of cotton fine roots to soil drought remains unclear. To elucidate the proteomic changes in fine roots of cotton plants under drought stress, 70–75% and 40–45% soil relative water content treatments were imposed on control (CK) and drought stress (DS) groups, respectively. Then, tandem mass tags (TMT) technology was used to determine the proteome profiles of fine root tissue samples. Results Drought significantly decreased the value of average root diameter of cotton seedlings, whereas the total root length and the activities of antioxidases were increased. To study the molecular mechanisms underlying drought response further, the proteome differences between tissues under CK and DS treatments were compared pairwise at 0, 30, and 45 DAD (days after drought stress). In total, 118 differentially expressed proteins (DEPs) were up-regulated and 105 were down-regulated in the ‘DS30 versus CK30’ comparison; 662 DEPs were up-regulated, and 611 were down-regulated in the ‘DS45 versus CK45’ comparison. The functions of these DEPs were classified according to their pathways. Under early stage drought (30 DAD), some DEPs involved in the ‘Cutin, suberin, and wax synthesis’ pathway were up-regulated, while the down-regulated DEPs were mainly enriched within the ‘Monoterpenoid biosynthesis’ pathway. Forty-five days of soil drought had a greater impact on DEPs involved in metabolism. Many proteins involving ‘Carbohydrate metabolism,’ ‘Energy metabolism,’ ‘Fatty acid metabolism,’ ‘Amino acid metabolism,’ and ‘Secondary metabolite biosynthesis’ were identified as DEPs. Additionally, proteins related to ion transport, stress/defense, and phytohormones were also shown to play roles in determining the fine root growth of cotton plants under drought stress. Conclusions Our study identified potential biological pathways and drought-responsive proteins related to stress/defense responses and plant hormone metabolism under drought stress. Collectively, our results provide new insights for further improving drought tolerance in cotton and other crops.
    Type of Medium: Online Resource
    ISSN: 1471-2229
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2059868-3
    SSG: 12
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  • 6
    In: Shock and Vibration, Hindawi Limited, Vol. 2021 ( 2021-11-11), p. 1-12
    Abstract: The research on charge induction and microseismic characteristics of coal and rock under different loading rates is of great significance for rockburst prediction. In this study, the coal and sandstone samples from the No. 11 mine of Pingdingshan Coal Mine are prepared. The charge induction and microseismic synchronous comprehensive monitoring system is built. The uniaxial compression tests of coal and sandstone samples under the different loading rates are conducted. The charge induction and microseismic signal characteristics in the deformation and fracture process of the coal and rock under the different loading rates are studied. The results show that, with the increase of loading rate, the compressive strength of the coal and rock samples increases and the time from the peak stress to instability failure becomes shorter. At the same loading rate, the softening failure stage time of coal is longer than that of sandstone. With the increase of loading rate, the duration of charge-induced signal and microseismic signal is longer and the events’ number and amplitude of charge signal and microseismic signal increase in the deformation and fracture process of the coal and rock. Before the instability failure, the charge-induced signal and microseismic signal have both synchronous and asynchronous signals, and the amplitude of charge-induced and microseismic signals in each channel is different, which is related to the distance from the position of each sensor to the fracture point of the sample. During the instability failure, the charge induction and microseismic signals of each channel are generated synchronously, and the signal amplitude reaches the maximum values of 50 pC and 6 × 10−3 m/s at the same time. With the increase of specimen stress, the dominant frequency of microseismic signals first increases and then decreases, while the amplitude of dominant frequency increases synchronously. The dominant frequency amplitude of microseismic signals is the largest in instability failure. With the increase of loading rate, the spectrum amplitude of microseismic signals changes little in the compaction stage, but the spectrum amplitude increases in other stages. At the same loading speed, the events’ number of the microseismic signal of coal samples after peak stress is more than that of sandstone samples, and the signal amplitude is also larger. However, the spectrum distribution range of microseismic signals of coal samples is wider than that of sandstone samples, and the spectrum amplitude of coal samples is lower than that of sandstone. With the increase of loading rate, the time of the first generation of high-amplitude signals is advanced, and the stress of specimen becomes smaller when the first generation of high-amplitude signals occurs. With the increase of loading rate, the duration of microseismic and charge signal is longer, and the mean square amplitude of charge signal is larger.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2070162-7
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  • 7
    Online Resource
    Online Resource
    IOP Publishing ; 2023
    In:  Journal of Physics: Conference Series Vol. 2427, No. 1 ( 2023-02-01), p. 012005-
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2427, No. 1 ( 2023-02-01), p. 012005-
    Abstract: With large-scale access to renewable energy, the configuration of energy storage systems has become an absolutely necessary way to improve the flexibility and reliability of power grid. To solve the problem of low utilization of traditional energy storage systems in a single scenario, this paper discusses the construction of a multi-scene energy storage scenario on the source-grid-load side. Taking the full-scene applications of energy storage in Jilin province for example, which accomplishes the goal of building a new power system with the interaction of all parties in the scenario, the optimal allocation of energy storage is realized, the utilization rate of energy is elevated, and the voltage stability of the grid is improved in the end.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2166409-2
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  • 8
    In: Journal of Colloid and Interface Science, Elsevier BV, Vol. 642 ( 2023-07), p. 273-282
    Type of Medium: Online Resource
    ISSN: 0021-9797
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1469021-4
    detail.hit.zdb_id: 241597-5
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  • 9
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 14 ( 2023-3-30)
    Abstract: Cerebral revascularization surgery is the mainstay of treatment for moyamoya syndrome (MMS) today, and intraoperative determination of the patency of the revascularized vessel is a critical factor in the success of the procedure. Currently, major imaging modalities include intraoperative indocyanine green (ICG) videoangiography (ICG-VA), digital subtraction angiography (DSA), and vascular ultrasound Doppler. Infrared thermography is a modern imaging modality with non-contact devices for the acquisition and analysis of thermal data. We aimed to investigate the feasibility and advantages of infrared thermography in determining anastomotic patency during MMS surgery. Methods Indocyanine green videoangiography and infrared thermography were performed simultaneously in 21 patients with MMS who underwent bypass surgery. The detection result of vessel patency was compared, and the feasibility and advantages of infrared thermography were assessed. Results The patency of the anastomosis was accurately determined in 21 patients using either ICG angiography or infrared thermography. In 20 patients, the results of infrared thermography showed that the vascular anastomosis was unobstructed, and there was an agreement with the subsequent results of ICG-VA. In one patient, we suspected inadequate patency after testing the anastomosis with infrared thermography, and the results of ICG-VA evaluation of the anastomosis confirmed that there was indeed an anastomotic obstruction. Conclusion Compared with ICG-VA, infrared thermography might offer an alternative non-invasive, contrast-free option in assessing anastomosis patency compared with ICG-VA, and it is likely to become more widely used in the clinic in the near future.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564214-5
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  • 10
    In: International Journal of Biological Macromolecules, Elsevier BV, Vol. 264 ( 2024-04), p. 130581-
    Type of Medium: Online Resource
    ISSN: 0141-8130
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1483284-7
    SSG: 12
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