In:
The Journal of Immunology, The American Association of Immunologists, Vol. 184, No. 1_Supplement ( 2010-04-01), p. 36.30-36.30
Abstract:
Despite negative selection, significant numbers of autoreactive T cells can be easily detected and expanded even in normal individuals. While lack of self antigen expression has been largely attributed as a key factor, we have reported that CD24, a GPI-anchored glycoprotein, regulates thymic deletion of autoreactive T lymphocytes. CD24-deficient 2D2 TCR transgenic mice (2D2+CD24-/-), whose TCR recognize myelin antigen MOG, failed to generate functional 2D2 T cells. Here we further show that elimination of MOG antigen expression in 2D2+CD24-/- mice (through creation of 2D2+CD24-/-MOG-/- mice), completely restored thymic cellularity and function of 2D2 T cells. Restoration of CD24 expression on dendritic cells, but not on thymocytes also restored 2D2 T cell generation in 2D2+CD24-/- mice. Taken together, we propose that CD24 expression on dendritic cells inhibits autoantigen-mediated deletion of autoreactive thymocytes.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.184.Supp.36.30
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2010
detail.hit.zdb_id:
1475085-5
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