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  • Oxford University Press (OUP)  (151)
  • Liu, Yang  (151)
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  • Oxford University Press (OUP)  (151)
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  • 1
    Online Resource
    Online Resource
    Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
    Oxford University Press (OUP) ; 2019
    In:  British Journal of Surgery Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Details
    In: British Journal of Surgery, Oxford University Press (OUP), Vol. 106, No. 2 ( 2019-01-08), p. e73-e80
    Abstract: The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs). Methods This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs. Results A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59). Conclusion Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally.
    Type of Medium: Online Resource
    ISSN: 0007-1323 , 1365-2168
    URL: Article
    DOI: 10.1002/bjs.11025
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2006309-X
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  • 2
    Online Resource
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    Physiological and biomass partitioning shifts to water stress under distinct soil types in Populus deltoides saplings
    Oxford University Press (OUP) ; 2020
    In:  Journal of Plant Ecology Vol. 13, No. 5 ( 2020-10-01), p. 545-553
    Details
    In: Journal of Plant Ecology, Oxford University Press (OUP), Vol. 13, No. 5 ( 2020-10-01), p. 545-553
    Abstract: Although soil environments exist extensive heterogeneity for many plants with a wide range of distribution, researches about effects of soil conditions on plants’ tolerance and adaptation are particularly inadequate. In our study, the aims are to reveal physiological strategies of Populus deltoides against drought stress under different soil conditions and to select the most suitable soil type for P. deltoides plantation. Methods Under controlled conditions, we used P. deltoides as a model species to detect differences in gas exchange rate, antioxidative capacity, nitrogen metabolism and biomass accumulation and partitioning in response to drought stress under three mineral soil types with distinct physicochemical characters, i.e. red soil (RS), yellow soil (YS) and yellow-brown soil (BS). Important Findings Exposure to 25% of field water holding capacity in soil for 3 months had significantly decreased biomass of all organs, photosynthetic rate, enzyme activities related to N assimilation, but increased H2O2, malondialdehyde and content of both NO3− and NH4+, when P. deltoides was planted in both RS and YS. In contrast, under BS, there are slightly negative effects exerted by water deficit on total biomass, gas exchange rate, activities of enzymes related to nitrogen metabolism and membrane damage caused by reactive oxygen species, which can be associated with a consistent increase in superoxide dismutase, peroxidase and catalase, and a higher ratio of root mass to shoot mass. It is concluded that, such higher capacity in tolerance and adaptation against drought stress under BS relative to both RS and YS could be accounted for more sufficient nutrient provision in soil parental materials and better soil aeration conditions which play a vital role in plant acclimation to water shortage. Our study also revealed that, distribution areas of BS might be preferable for cultivation of P. deltoides, when compared with those of RS and YS.
    Type of Medium: Online Resource
    ISSN: 1752-993X
    URL: Article
    DOI: 10.1093/jpe/rtaa042
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2381013-0
    SSG: 12
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  • 3
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    Altered Profile of Seminal Plasma MicroRNAs in the Molecular Diagnosis of Male Infertility
    Oxford University Press (OUP) ; 2011
    In:  Clinical Chemistry Vol. 57, No. 12 ( 2011-12-01), p. 1722-1731
    Details
    In: Clinical Chemistry, Oxford University Press (OUP), Vol. 57, No. 12 ( 2011-12-01), p. 1722-1731
    Abstract: Although microRNAs (miRNAs) play essential roles in spermatogenesis, little is known about seminal plasma miRNAs in infertile men. We investigated the profile of seminal plasma miRNAs in infertile men to identify miRNAs that are altered in infertility; we then evaluated their diagnostic value. METHODS Seminal plasma samples were obtained from 289 infertile men and 168 age-matched fertile control individuals. The stability of the miRNAs was first assessed by time-course and freeze–thaw cycle analyses. The Solexa sequencing technology was used for an initial screen of the miRNAs in samples pooled from 45 patients with nonobstructive azoospermia, 58 patients with asthenozoospermia, and 100 fertile controls. A stem–loop quantitative reverse-transcription PCR (RT-qPCR) assay was conducted in the training and verification sets to confirm the concentrations of the altered miRNAs in 73 patients with nonobstructive azoospermia, 79 patients with asthenozoospermia, 34 patients with oligospermia, and 68 fertile controls. RESULTS The miRNAs in seminal plasma were stable. The Solexa sequencing analysis demonstrated 19 markedly altered miRNAs in the patient groups, compared with the control group. RT-qPCR analysis identified 7 miRNAs (miR-34c-5p, miR-122, miR-146b-5p, miR-181a, miR-374b, miR-509–5p, and miR-513a-5p) as markedly decreased in azoospermia but increased in asthenozoospermia. The area under the ROC curve for these miRNAs ranged from 0.733 to 0.921, markedly higher than for routine biochemical parameters (0.510–0.622). Moreover, the concentrations of some selected miRNAs were also increased in the semen sperm of the asthenozoospermia patients. CONCLUSIONS The measurement of miRNAs in seminal plasma provides a novel, noninvasive approach for diagnosing male infertility.
    Type of Medium: Online Resource
    ISSN: 0009-9147 , 1530-8561
    URL: Article
    DOI: 10.1373/clinchem.2011.169714
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
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  • 4
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    Online Resource
    Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool
    Oxford University Press (OUP) ; 2020
    In:  National Science Review Vol. 7, No. 5 ( 2020-05-01), p. 913-920
    Details
    In: National Science Review, Oxford University Press (OUP), Vol. 7, No. 5 ( 2020-05-01), p. 913-920
    Abstract: Chang’E-4 landed in the South Pole-Aitken (SPA) basin, providing a unique chance to probe the composition of the lunar interior. Its landing site is located on ejecta strips in Von Kármán crater that possibly originate from the neighboring Finsen crater. A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations. In situ spectra of the regolith have peak band positions at 1 and 2 μm, similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper, which confirms that the regolith's composition of the landing area is mostly similar to that of Finsen ejecta. The rock spectrum shows similar band peak positions, but stronger absorptions, suggesting relatively fresh exposure. The rock may consist of 38.1 ± 5.4% low-Ca pyroxene, 13.9 ± 5.1% olivine and 48.0 ± 3.1% plagioclase, referred to as olivine-norite. The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle, but representative of the lunar lower crust. Alternatively, the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials. This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool, indicated by the fine to medium-sized texture ( & lt;3 mm) of the rock and the SPA-impact melting model [Icarus 2012; 220: 730–43].
    Type of Medium: Online Resource
    ISSN: 2095-5138 , 2053-714X
    URL: Article
    DOI: 10.1093/nsr/nwz183
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2745465-4
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  • 5
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    TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response
    Oxford University Press (OUP) ; 2022
    In:  Nucleic Acids Research Vol. 50, No. D1 ( 2022-01-07), p. D1391-D1397
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 50, No. D1 ( 2022-01-07), p. D1391-D1397
    Abstract: Syngeneic mouse models are tumors derived from murine cancer cells engrafted on genetically identical mouse strains. They are widely used tools for studying tumor immunity and immunotherapy response in the context of a fully functional murine immune system. Large volumes of syngeneic mouse tumor expression profiles under different immunotherapy treatments have been generated, although a lack of systematic collection and analysis makes data reuse challenging. We present Tumor Immune Syngeneic MOuse (TISMO), a database with an extensive collection of syngeneic mouse model profiles with interactive visualization features. TISMO contains 605 in vitro RNA-seq samples from 49 syngeneic cancer cell lines across 23 cancer types, of which 195 underwent cytokine treatment. TISMO also includes 1518 in vivo RNA-seq samples from 68 syngeneic mouse tumor models across 19 cancer types, of which 832 were from immune checkpoint blockade (ICB) studies. We manually annotated the sample metadata, such as cell line, mouse strain, transplantation site, treatment, and response status, and uniformly processed and quality-controlled the RNA-seq data. Besides data download, TISMO provides interactive web interfaces to investigate whether specific gene expression, pathway enrichment, or immune infiltration level is associated with differential immunotherapy response. TISMO is available at http://tismo.cistrome.org.
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    URL: Article
    DOI: 10.1093/nar/gkab804
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis
    Oxford University Press (OUP) ; 2021
    In:  Protein & Cell Vol. 12, No. 1 ( 2021-01), p. 57-66
    Details
    In: Protein & Cell, Oxford University Press (OUP), Vol. 12, No. 1 ( 2021-01), p. 57-66
    Type of Medium: Online Resource
    ISSN: 1674-800X , 1674-8018
    URL: Article
    DOI: 10.1007/s13238-020-00763-1
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2543451-2
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  • 7
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    Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells
    Oxford University Press (OUP) ; 2021
    In:  Carcinogenesis Vol. 42, No. 5 ( 2021-05-28), p. 753-761
    Details
    In: Carcinogenesis, Oxford University Press (OUP), Vol. 42, No. 5 ( 2021-05-28), p. 753-761
    Abstract: Sorafenib is commonly used to treat advanced human hepatocellular carcinoma (HCC). However, clinical efficacy has been limited by drug resistance. In this study, we used label-free quantitative proteomic analysis to systematically investigate the underlying mechanisms of sorafenib resistance in HCC cells. A total of 1709 proteins were confidently quantified. Among them, 89 were differentially expressed and highly enriched in the processes of cell–cell adhesion, negative regulation of apoptosis, response to drug and metabolic processes involving in sorafenib resistance. Notably, folate receptor α (FOLR1) was found to be significantly upregulated in resistant HCC cells. In addition, in vitro studies showed that overexpression of FOLR1 decreased the sensitivity of HCC cells to sorafenib, whereas siRNA-directed knockdown of FOLR1 increased the sensitivity of HCC cells to sorafenib. Immunoprecipitation-mass spectrometry analysis suggested a strong link between FOLR1 and autophagy-related proteins. Further biological experiments found that FOLR1-related sorafenib resistance was accompanied by the activation of autophagy, whereas inhibition of autophagy significantly reduced FOLR1-induced cell resistance. These results suggest the driving role of FOLR1 in HCC resistance to sorafenib, which may be exerted through FOLR1-induced autophagy. Therefore, this study may provide new insights into understanding the mechanism of sorafenib resistance.
    Type of Medium: Online Resource
    ISSN: 0143-3334 , 1460-2180
    URL: Article
    DOI: 10.1093/carcin/bgab019
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1474206-8
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  • 8
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    Preliminary study on radiosensitivity to carbon ions in human breast cancer
    Oxford University Press (OUP) ; 2020
    In:  Journal of Radiation Research Vol. 61, No. 3 ( 2020-05-22), p. 399-409
    Details
    In: Journal of Radiation Research, Oxford University Press (OUP), Vol. 61, No. 3 ( 2020-05-22), p. 399-409
    Abstract: The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (12C6+) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms of radiation sensitivity. Cell proliferation, cell colony formation, cell cycle distribution, cell apoptosis and protein expression levels [double-strand break marker γ-H2AX, cell cycle-related protein cyclin B1, apoptosis-related proteins Bax and Bcl-2, and the Akt/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase B1 (p70S6K) pathway] were detected after irradiation with carbon ions or X-rays at doses of 0, 2, 4 and 8 Gy. Our results showed that the inhibition of cell proliferation and cell colony formation and the induction of G2/M phase arrest, DNA lesions and cell apoptosis/necrosis elicited by carbon ion irradiation were more potent than the effects elicited by X-ray radiation at the same dose. Simultaneously, compared with X-ray radiation, carbon ion radiation induced a marked increase in Bax and prominent decreases in cyclin B1 and Bcl-2 in a dose-dependent manner. Furthermore, the Akt/mTOR/p70S6K pathway was significantly inhibited by carbon ion radiation in both breast cancer cell lines. These results indicate that carbon ion rad iation kills MDA-MB-231 and MCF-7 breast cancer cells more effectively than X-ray radiation, which might result from the inhibition of the Akt/mTOR/p70S6K pathway.
    Type of Medium: Online Resource
    ISSN: 0449-3060 , 1349-9157
    URL: Article
    DOI: 10.1093/jrr/rraa017
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2038914-0
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  • 9
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    The efficacy and safety of intermittent preventive treatment with sulphadoxine-pyrimethamine vs artemisinin-based drugs for malaria: a systematic review and meta-analysis
    Oxford University Press (OUP) ; 2022
    In:  Transactions of The Royal Society of Tropical Medicine and Hygiene Vol. 116, No. 4 ( 2022-04-04), p. 298-309
    Details
    In: Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), Vol. 116, No. 4 ( 2022-04-04), p. 298-309
    Abstract: Malaria is one of the most serious global problems. The objective of this study is to assess whether intermittent preventive treatment (IPT) using artemisinin-based combination therapies (ACTs) was a promising alternative to IPT with sulphadoxine-pyrimethamine (IPT-SP). Methods We searched the following sources up to 12 August 2020: PubMed, The Cochrane Library, Embase, Web of Science, CNKI, CBM, VIP and WanFang Database from inception. The randomized controlled trials comparing SP with ACTs for malaria were included. Data were pooled using Stata.14 software. We performed subgroup analysis based on the different types of ACTs groups and participants. Results A total of 13 studies comprising 5180 people were included. The meta-analysis showed that ACTs had the lower risk of number of any parasitemia (RR=0.46; 95% CI 0.22 to 0.96, p=0.039; I2=90.50%, p & lt;0.001), early treatment failure (RR=0.17; 95% CI 0.06 to 0.48, p & lt;0.001; I2=66.60%, p=0.011) and late treatment failure (RR=0.34; 95% CI 0.13 to 0.92, p & lt;0.001; I2=87.80%, p & lt;0.001) compared with SP. There was no significant difference in adequate clinical response, average hemoglobin and adverse neonatal outcomes. Conclusion Combinations with ACTs appear promising as suitable alternatives for IPT-SP.
    Type of Medium: Online Resource
    ISSN: 0035-9203 , 1878-3503
    URL: Article
    DOI: 10.1093/trstmh/trab158
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2135136-3
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  • 10
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    The sex-based disparity in BMI-for-age z-score trends among Xinjiang children and adolescents using four rounds of cross-sectional surveys from 1985 to 2014
    Oxford University Press (OUP) ; 2020
    In:  Journal of Public Health Vol. 42, No. 4 ( 2020-11-23), p. 731-739
    Details
    In: Journal of Public Health, Oxford University Press (OUP), Vol. 42, No. 4 ( 2020-11-23), p. 731-739
    Abstract: This study aimed to evaluate trends in body mass index (BMI)-for-age z-scores among children and adolescents in Xinjiang. Methods Data were obtained for children and adolescents aged 7–18 years in Xinjiang from the Chinese National Survey on Students’ Constitution and Health (CNSSCH) in 1985 (n = 14 683), 1995 (n = 7198), 2005 (n = 10 253) and 2014 (n = 18 521). Results The BMI-for-age z-score distribution of children and adolescents in Xinjiang showed an increased mean BMI-for-age z-score, dispersion and right-skewed of BMI-values, with a rapid increase in BMI with increasing BMI percentiles. The sex-based disparity in BMI-for-age z-scores became wider in the past 30 years. Conclusions Sex-based targeted public health measures and policies are urgently needed in Xinjiang. The rapid increases in the upper percentiles also implicated further efforts to prevent weight gain in those living already with overweight or obesity.
    Type of Medium: Online Resource
    ISSN: 1741-3842 , 1741-3850
    URL: Article
    DOI: 10.1093/pubmed/fdz189
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1497445-9
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